S-{[Bis(4-methoxyphenyl)phosphanyl]methyl} ethanethioate

Base Information

• Chemical Name: S-{[Bis(4-methoxyphenyl)phosphanyl]methyl} ethanethioate
• CAS No.: 922517-77-9
• Molecular Formula: C17H19O3PS
• Molecular Weight: 334.376
• DSSTox Substance ID: DTXSID40580215
• Wikidata: Q82470988
• Mol file: 922517-77-9.mol

Synonyms:922517-77-9;S-((Bis(4-methoxyphenyl)phosphino)methyl) ethanethioate;S-{[Bis(4-methoxyphenyl)phosphanyl]methyl} ethanethioate;DTXSID40580215

Chemical Property of S-{[Bis(4-methoxyphenyl)phosphanyl]methyl} ethanethioate

Chemical Property:

• XLogP3: 3.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 7
• Exact Mass: 334.07925264
• Heavy Atom Count: 22
• Complexity: 313

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)SCP(C1=CC=C(C=C1)OC)C2=CC=C(C=C2)OC

Technology Process of S-{[Bis(4-methoxyphenyl)phosphanyl]methyl} ethanethioate

There total 3 articles about S-{[Bis(4-methoxyphenyl)phosphanyl]methyl} ethanethioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

thioacetic acid S-[bis-(4-methoxy-phenyl)-phosphinoylmethyl] ester (922517-75-7) → thioacetic acid S-{[bis-(4-methoxy-phenyl)-phosphanyl]-methyl} ester (922517-77-9)

Guidance literature:

With trichlorosilane; In chloroform; for 72h;

DOI:10.1021/jo0620056

Reference yield:

C15H16ClO3P (13685-40-0) → thioacetic acid S-{[bis-(4-methoxy-phenyl)-phosphanyl]-methyl} ester (922517-77-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 87 percent / dimethylformamide / 18 h

2: 92 percent / trichlorosilane / CHCl₃ / 72 h

With trichlorosilane; In chloroform; N,N-dimethyl-formamide;

DOI:10.1021/jo0620056

Reference yield:

4-methoxyphenyl magnesium bromide (13139-86-1) → thioacetic acid S-{[bis-(4-methoxy-phenyl)-phosphanyl]-methyl} ester (922517-77-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 63 percent / tetrahydrofuran / 24 h / Heating

2: 87 percent / dimethylformamide / 18 h

3: 92 percent / trichlorosilane / CHCl₃ / 72 h

With trichlorosilane; In tetrahydrofuran; chloroform; N,N-dimethyl-formamide;

DOI:10.1021/jo0620056

upstream raw materials:

thioacetic acid S-[bis-(4-methoxy-phenyl)-phosphinoylmethyl] ester

C₁₅H₁₆ClO₃P

4-methoxyphenyl magnesium bromide

Downstream raw materials:

2-acetylamino-3-phenyl-thiopropionic acid S-{[bis-(4-methoxy-phenyl)-phosphanyl]-methyl} ester

2-acetylamino-thiopropionic acid S-{[bis-(4-methoxy-phenyl)-phosphanyl]-methyl} ester

di(4-methoxyphenyl)phosphinomethanethiol