Propanoic acid, 2,2-dimethyl-, (1R,2E)-4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-[(1R,2S,5R)-5-methyl -2-(1-methylethyl)cyclohexyl]-2-buten-1-yl ester

Base Information

Chemical Name:Propanoic acid, 2,2-dimethyl-, (1R,2E)-4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-[(1R,2S,5R)-5-methyl -2-(1-methylethyl)cyclohexyl]-2-buten-1-yl ester
CAS No.:922734-71-2
Molecular Formula:C25H48O3Si
Molecular Weight:424.74
Hs Code.:

Propanoic acid, 2,2-dimethyl-,
(1R,2E)-4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-[(1R,2S,5R)-5-methyl
-2-(1-methylethyl)cyclohexyl]-2-buten-1-yl ester

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Chemical Property of Propanoic acid, 2,2-dimethyl-, (1R,2E)-4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-[(1R,2S,5R)-5-methyl -2-(1-methylethyl)cyclohexyl]-2-buten-1-yl ester

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Technology Process of Propanoic acid, 2,2-dimethyl-, (1R,2E)-4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-[(1R,2S,5R)-5-methyl -2-(1-methylethyl)cyclohexyl]-2-buten-1-yl ester

There total 4 articles about Propanoic acid, 2,2-dimethyl-, (1R,2E)-4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-[(1R,2S,5R)-5-methyl -2-(1-methylethyl)cyclohexyl]-2-buten-1-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 868744-80-3
(E)-(R)-4-(tert-Butyl-dimethyl-silanyloxy)-1-((1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl)-but-2-en-1-ol

: 3282-30-2
pivaloyl chloride

: 922734-71-2
2,2-dimethyl-propionic acid 4-(tert-butyl-dimethyl-silanyloxy)-1-(2-isopropyl-5-methyl-cyclohexyl)-but-2-enyl ester

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃;
DOI:10.1139/V06-095

Reference yield:

: 922734-67-6
4-(tert-butyl-dimethyl-silanyloxy)-1-(2-isopropyl-5-methyl-cyclohexyl)-but-2-yn-1-ol

: 922734-71-2
2,2-dimethyl-propionic acid 4-(tert-butyl-dimethyl-silanyloxy)-1-(2-isopropyl-5-methyl-cyclohexyl)-but-2-enyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 82 percent / Red-Al / tetrahydrofuran; toluene / 96 h / -25 °C

2: 94 percent / triethylamine / CH₂Cl₂ / 0 - 20 °C

With triethylamine; sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1139/V06-095

Reference yield:

: 76782-82-6
tert-Butyldimethyl(prop-2-ynyloxy)silane

: 922734-71-2
2,2-dimethyl-propionic acid 4-(tert-butyl-dimethyl-silanyloxy)-1-(2-isopropyl-5-methyl-cyclohexyl)-but-2-enyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-BuLi / tetrahydrofuran; hexane / 1.25 h / -78 - 0 °C

1.2: 53 percent / cerium(III) chloride / tetrahydrofuran; hexane / 12 h / -78 - 20 °C

2.1: 82 percent / Red-Al / tetrahydrofuran; toluene / 96 h / -25 °C

3.1: 94 percent / triethylamine / CH₂Cl₂ / 0 - 20 °C

With n-butyllithium; triethylamine; sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; hexane; dichloromethane; toluene;
DOI:10.1139/V06-095