Folpet

Base Information

• Chemical Name: Folpet
• CAS No.: 133-07-3
• Deprecated CAS: 52306-33-9,1135442-81-7,1135442-81-7
• Molecular Formula: C9H4Cl3NO2S
• Molecular Weight: 296.561
• Hs Code.: 29309090
• European Community (EC) Number: 205-088-6
• ICSC Number: 0156
• UN Number: 3077,2588
• UNII: X5NFK36917
• DSSTox Substance ID: DTXSID0021385
• Nikkaji Number: J2.948C
• Wikipedia: Folpet
• Wikidata: Q426485
• Metabolomics Workbench ID: 45104
• ChEMBL ID: CHEMBL1883819
• Mol file: 133-07-3.mol

Synonyms:folpet;Phaltan

Chemical Property of Folpet

Chemical Property:

• Appearance/Colour: White crystals
• Vapor Pressure: 0.000133mmHg at 25°C
• Melting Point: 177-180 °C
• Refractive Index: 1.693
• Boiling Point: 333.8 °C at 760 mmHg
• PKA: -3.34±0.20(Predicted)
• Flash Point: 155.7 °C
• PSA: 62.68000
• Density: 1.74 g/cm³
• LogP: 3.19640
• Storage Temp.: 0-6°C
• Water Solubility.: practically insoluble
• XLogP3: 2.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 294.902833
• Heavy Atom Count: 16
• Complexity: 307
• Transport DOT Label: Class 9

Purity/Quality:

99% ^*data from raw suppliers

Folpet ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn,N
• Hazard Codes: Xn,N
• Statements: 20-36-40-43-50
• Safety Statements: 36/37-46-61

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Pesticides -> Fungicides
• Canonical SMILES: C1=CC=C2C(=C1)C(=O)N(C2=O)SC(Cl)(Cl)Cl
• Inhalation Risk: A nuisance-causing concentration of airborne particles can be reached quickly when dispersed.
• Effects of Short Term Exposure: The substance is irritating to the eyes.
• Effects of Long Term Exposure: Repeated or prolonged contact with skin may cause dermatitis. Repeated or prolonged contact may cause skin sensitization. The substance may have effects on the gastrointestinal tract. Tumours have been detected in experimental animals but may not be relevant to humans.
• Description: Folpet is practically insoluble in water. It is a protective leaf fungicide. Its mode of action inhibits normal cell division of a broad spectrum of microorganisms. It is used to control cherry leaf spot, rose mildew, rose black spot, and apple scab. It is used on berries, flowers, ornamentals, fruits, and vegetables and for seedand plant-bed treatment. It is also used as a fungicide in paints and plastics and for treatment of internal and external structural surfaces of buildings. It is incompatible with strongly alkaline preparations, such as lime sulphur.
• Uses: Folpet is used to control downy mildews, powdery mildews, leaf spot diseases, scab and rots in fruit, ornamentals and vegetables. Agricultural fungicide. Folpet is a pesticide, fungicide agent from the thiophtalimide group. Occupational exposure occurs mostly in agricultural workers or in florists.

Technology Process of Folpet

There total 4 articles about Folpet which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

phthalimide (136918-14-4,85-41-6) + chlorothio-trichloro-methane (594-42-3) → 2-trichloromethylthio-1H-isoindole-1,3(2H)-dione (133-07-3)

Guidance literature:

phthalimide; With sodium hydroxide; In water; at 10 - 15 ℃;

chlorothio-trichloro-methane; In water; toluene; at 10 - 15 ℃;

Reference yield:

potassium phtalimide (1074-82-4) + chlorothio-trichloro-methane (594-42-3) → 2-trichloromethylthio-1H-isoindole-1,3(2H)-dione (133-07-3)

Guidance literature:

With benzene; at 50 - 60 ℃;

DOI:10.1007/BF00638264

Reference yield:

→ 2-trichloromethylthio-1H-isoindole-1,3(2H)-dione (133-07-3)

Guidance literature:

Cl3C-S-Cl, Phthalimid;

DOI:10.1055/s-1975-23696

upstream raw materials:

potassium phtalimide

chlorothio-trichloro-methane

phthalimide

Downstream raw materials:

phthalimide

benzene-1,2-dicarboxylic acid

iron(II) tetraphenylporphyrin (thiophthalimido)chlorocarbene

C₁₅H₁₄Cl₃NO₂S

Refernces

• 1、 Carle, A. Bjoern,Krause Bauer, Jeanette A.,Wilson, R. Marshall. "2-Trichloromethylthio-1H-isoindole-1,3(2H)-dione (Folpet)". . p. 97 - 98. Retrieved 2000.
• 2、 -. "Protective agents for wood". . . Retrieved 2008/06/13.