Benzenesulfonamide, N-[(3R)-1-[(1R)-1-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-2-methyl propyl]-3-methyl-2-oxo-3-azetidinyl]-2-nitro-

Base Information

Chemical Name:Benzenesulfonamide, N-[(3R)-1-[(1R)-1-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-2-methyl propyl]-3-methyl-2-oxo-3-azetidinyl]-2-nitro-
CAS No.:923579-25-3
Molecular Formula:C21H35N3O6SSi
Molecular Weight:485.677
Hs Code.:

Benzenesulfonamide,
N-[(3R)-1-[(1R)-1-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-2-methyl
propyl]-3-methyl-2-oxo-3-azetidinyl]-2-nitro-

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Benzenesulfonamide, N-[(3R)-1-[(1R)-1-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-2-methyl propyl]-3-methyl-2-oxo-3-azetidinyl]-2-nitro-

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MSDS Files:: SDS file from LookChem

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Technology Process of Benzenesulfonamide, N-[(3R)-1-[(1R)-1-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-2-methyl propyl]-3-methyl-2-oxo-3-azetidinyl]-2-nitro-

There total 5 articles about Benzenesulfonamide, N-[(3R)-1-[(1R)-1-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-2-methyl propyl]-3-methyl-2-oxo-3-azetidinyl]-2-nitro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 923579-19-5
methyl (R)-2-methyl-3-[(R)-2-(tert-butyldimethylsilyloxy)-1-propylamino]-2-(2-nitrobenzenesulfonylamino)-propanoate

: 923579-25-3
(3R)-1-[(1R)-2-(tert-butyldimethylsilyloxy)-1-isopropyl-ethyl]-3-methyl-3-(2-nitrobenzenesulfonylamino)-azetidin-2-one

Guidance literature:: With lithium hexamethyldisilazane; In tetrahydrofuran; at 0 ℃; for 12h;
DOI:10.1021/ol0626241

Reference yield:

: 4276-09-9,473-75-6
(R)-2-amino-3-methylbutanol

: 923579-25-3
(3R)-1-[(1R)-2-(tert-butyldimethylsilyloxy)-1-isopropyl-ethyl]-3-methyl-3-(2-nitrobenzenesulfonylamino)-azetidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / Et₃N / CH₂Cl₂ / 12 h / 20 °C

2: 45 percent / acetonitrile / 20 h / 20 °C

3: 98 percent / LiHMDS / tetrahydrofuran / 12 h / 0 °C

With triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1021/ol0626241

Reference yield:

: 923578-92-1
(R)-2-amino-3-methyl-1-(tert-butyldimethylsilyloxy)butane

: 923579-25-3
(3R)-1-[(1R)-2-(tert-butyldimethylsilyloxy)-1-isopropyl-ethyl]-3-methyl-3-(2-nitrobenzenesulfonylamino)-azetidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 45 percent / acetonitrile / 20 h / 20 °C

2: 98 percent / LiHMDS / tetrahydrofuran / 12 h / 0 °C

With lithium hexamethyldisilazane; In tetrahydrofuran; acetonitrile;
DOI:10.1021/ol0626241