L-Alanine, 2-[[[(1R)-1-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-2-methylpropyl] amino]methyl]-N-[(2-nitrophenyl)sulfonyl]-, methyl ester

Base Information

Chemical Name:L-Alanine, 2-[[[(1R)-1-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-2-methylpropyl] amino]methyl]-N-[(2-nitrophenyl)sulfonyl]-, methyl ester
CAS No.:923579-19-5
Molecular Formula:C22H39N3O7SSi
Molecular Weight:517.719
Hs Code.:

L-Alanine,
2-[[[(1R)-1-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-2-methylpropyl]
amino]methyl]-N-[(2-nitrophenyl)sulfonyl]-, methyl ester

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of L-Alanine, 2-[[[(1R)-1-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-2-methylpropyl] amino]methyl]-N-[(2-nitrophenyl)sulfonyl]-, methyl ester

Chemical Property:

Purity/Quality:

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Hazard Codes:

MSDS Files:: SDS file from LookChem

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Technology Process of L-Alanine, 2-[[[(1R)-1-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-2-methylpropyl] amino]methyl]-N-[(2-nitrophenyl)sulfonyl]-, methyl ester

There total 5 articles about L-Alanine, 2-[[[(1R)-1-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-2-methylpropyl] amino]methyl]-N-[(2-nitrophenyl)sulfonyl]-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 923578-92-1
(R)-2-amino-3-methyl-1-(tert-butyldimethylsilyloxy)butane

: 923578-98-7
(2R)-2-methyl-2-methoxycarbonyl-1-(2-nitrobenzenesulfonyl)-aziridine

: 923579-19-5
methyl (R)-2-methyl-3-[(R)-2-(tert-butyldimethylsilyloxy)-1-propylamino]-2-(2-nitrobenzenesulfonylamino)-propanoate

Guidance literature:: In acetonitrile; at 20 ℃; for 20h;
DOI:10.1021/ol0626241

Reference yield:

: 4276-09-9,473-75-6
(R)-2-amino-3-methylbutanol

: 923579-19-5
methyl (R)-2-methyl-3-[(R)-2-(tert-butyldimethylsilyloxy)-1-propylamino]-2-(2-nitrobenzenesulfonylamino)-propanoate

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / Et₃N / CH₂Cl₂ / 12 h / 20 °C

2: 45 percent / acetonitrile / 20 h / 20 °C

With triethylamine; In dichloromethane; acetonitrile;
DOI:10.1021/ol0626241

Reference yield:

: (2S,4R)-4-methyl-2-(tert-butyl)-3-formyl-4-methoxycarbonyl-1,3-oxazolidine

: 923579-19-5
methyl (R)-2-methyl-3-[(R)-2-(tert-butyldimethylsilyloxy)-1-propylamino]-2-(2-nitrobenzenesulfonylamino)-propanoate

Guidance literature:: Multi-step reaction with 3 steps

1: 97 percent / HCl / methanol; H₂O / 7 h / Heating

2: 85 percent / KHCO₃ / acetonitrile / 16 h / Heating

3: 45 percent / acetonitrile / 20 h / 20 °C

With hydrogenchloride; potassium hydrogencarbonate; In methanol; water; acetonitrile;
DOI:10.1021/ol0626241