2-Benzyl-4-bromoisoindoline

Base Information

• Chemical Name: 2-Benzyl-4-bromoisoindoline
• CAS No.: 923590-78-7
• Molecular Formula: C15H14BrN
• Molecular Weight: 288.187
• Hs Code.: 2933990090
• Mol file: 923590-78-7.mol

Synonyms:2-benzyl-4-bromo-isoindoline;

Chemical Property of 2-Benzyl-4-bromoisoindoline

Chemical Property:

• Boiling Point: 354 °C at 760 mmHg
• Flash Point: 167.9 °C
• PSA: 3.24000
• Density: 1.412 g/cm³
• LogP: 3.90280
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

2-Benzyl-4-bromoisoindoline 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Benzyl-4-bromoisoindoline

There total 3 articles about 2-Benzyl-4-bromoisoindoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

3-bromo-1,2-bis(bromomethyl)benzene (127168-82-5) + benzylamine (100-46-9) → 2-benzyl-4-bromoisoindoline (923590-78-7)

Guidance literature:

With potassium carbonate; In acetonitrile; at 77 - 80 ℃; for 17h; Inert atmosphere;

DOI:10.1021/jm9015526

Reference yield:

2,3-dimethylbromobenzene (576-23-8) → 2-benzyl-4-bromoisoindoline (923590-78-7)

Guidance literature:

Multi-step reaction with 2 steps

1: N-Bromosuccinimide / dibenzoyl peroxide / tetrachloromethane / 15 h / Reflux; Inert atmosphere

2: potassium hydrogensulfate / acetonitrile / 17 h / 77 - 80 °C

With potassium hydrogensulfate; N-Bromosuccinimide; dibenzoyl peroxide; In tetrachloromethane; acetonitrile;

Reference yield:

2-benzyl-4-bromoisoindoline hydrochloride (923590-92-5) → 2-benzyl-4-bromoisoindoline (923590-78-7)

Guidance literature:

With sodium hydroxide; In water; ethyl acetate; for 0.5h; Product distribution / selectivity;

upstream raw materials:

3-bromo-1,2-bis(bromomethyl)benzene

benzylamine

2-benzyl-4-bromoisoindoline hydrochloride

2,3-dimethylbromobenzene

Downstream raw materials:

4-bromo-2,3-dihydro-1H-isoindole hydrochloride

4-vinylisoindoline

2-benzyl-4-bromoisoindoline hydrochloride

2-benzyl-4-vinylisoindoline

Refernces

• 1、 -. "ARYL LINKED IMIDAZOLE AND TRIAZOLE DERIVATIVES AND METHODS OF USE THEREOF FOR IMPROVING THE PHARMACOKINETICS OF A DRUG". Page/Page column 53; 54. . Retrieved 2015/06/03.
• 2、 -. "HCV NS3 PROTEASE INHIBITORS". Page/Page column 50. . Retrieved 2012/04/10.