2-benzyl-4-vinylisoindoline

Base Information

• Chemical Name: 2-benzyl-4-vinylisoindoline
• CAS No.: 923590-80-1
• Molecular Formula: C17H17N
• Molecular Weight: 235.329
• Mol file: 923590-80-1.mol

Synonyms:2-benzyl-4-vinylisoindoline;

Chemical Property of 2-benzyl-4-vinylisoindoline

Chemical Property:

• PSA: 3.24000
• LogP: 3.78330

Purity/Quality:

95+% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-benzyl-4-vinylisoindoline

There total 4 articles about 2-benzyl-4-vinylisoindoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

2-benzyl-4-bromoisoindoline (923590-78-7) + tri-n-butyl(vinyl)tin (7486-35-3) → 2-benzyl-4-vinylisoindoline (923590-80-1)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In toluene; at 100 ℃; for 24h; Inert atmosphere;

DOI:10.1021/jm9015526

Reference yield:

2-benzyl-4-bromoisoindoline hydrochloride (923590-92-5) + tri-n-butyl(vinyl)tin (7486-35-3) → 2-benzyl-4-vinylisoindoline (923590-80-1)

Guidance literature:

tetrakis(triphenylphosphine) palladium⁽⁰⁾; In toluene; at 100 ℃; for 24.25h;

Reference yield:

2,3-dimethylbromobenzene (576-23-8) → 2-benzyl-4-vinylisoindoline (923590-80-1)

Guidance literature:

Multi-step reaction with 3 steps

1: N-Bromosuccinimide / dibenzoyl peroxide / tetrachloromethane / 15 h / Reflux; Inert atmosphere

2: potassium hydrogensulfate / acetonitrile / 17 h / 77 - 80 °C

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 24 h / 100 °C / Inert atmosphere

With potassium hydrogensulfate; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dibenzoyl peroxide; In tetrachloromethane; toluene; acetonitrile;

upstream raw materials:

2-benzyl-4-bromoisoindoline

tri-n-butyl(vinyl)tin

2-benzyl-4-bromoisoindoline hydrochloride

2,3-dimethylbromobenzene

Downstream raw materials:

4-vinylisoindoline

Refernces

• 1、 -. "HCV NS3 PROTEASE INHIBITORS". Page/Page column 51. . Retrieved 2012/04/10.
• 2、 -. "Macrocyclic Compounds as Antiviral Agents". . . Retrieved 2009/12/27.