Technology Process of 2-benzyl-4-bromoisoindoline hydrochloride
There total 4 articles about 2-benzyl-4-bromoisoindoline hydrochloride which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogenchloride;
In
methanol;
Product distribution / selectivity;
- Guidance literature:
-
3-bromo-1,2-bis(bromomethyl)benzene; benzylamine;
With
potassium hydrogencarbonate;
In
acetonitrile;
at 20 - 80 ℃;
for 20h;
With
potassium carbonate;
In
water; ethyl acetate;
pH=> 9;
With
hydrogenchloride;
In
methanol; ethanol; tert-butyl methyl ether;
at 0 ℃;
for 15h;
Product distribution / selectivity;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: N-Bromosuccinimide / dibenzoyl peroxide / tetrachloromethane / 15 h / Reflux; Inert atmosphere
2: potassium hydrogensulfate / acetonitrile / 17 h / 77 - 80 °C
3: hydrogenchloride / methanol
With
hydrogenchloride; potassium hydrogensulfate; N-Bromosuccinimide;
dibenzoyl peroxide;
In
methanol; tetrachloromethane; acetonitrile;
