Methyl 1-aMinocyclooctanecarboxylate hydrochloride

Base Information

• Chemical Name: Methyl 1-aMinocyclooctanecarboxylate hydrochloride
• CAS No.: 92398-52-2
• Molecular Formula: C10H19NO2.ClH
• Molecular Weight: 221.727
• Mol file: 92398-52-2.mol

Synonyms:METHYL 1-AMINO-1-CYCLOOCTANECARBOXYLATE HCL;Cyclooctanecarboxylic acid,1-amino-,methyl ester,hydrochloride;methyl 1-aminocyclooctanecarboxylate hydrochloride;

Chemical Property of Methyl 1-aMinocyclooctanecarboxylate hydrochloride

Chemical Property:

• PSA: 52.32000
• LogP: 3.10350

Purity/Quality:

95+% ^*data from raw suppliers

Methyl1-aminocyclooctanecarboxylatehydrochloride 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 1-aMinocyclooctanecarboxylate hydrochloride

There total 4 articles about Methyl 1-aMinocyclooctanecarboxylate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

methanol (67-56-1) + 1-aminocyclooctane-1-carboxylic acid (28248-38-6) → methyl 1-aminocyclooctanecarboxylate hydrochloride (92398-52-2)

Guidance literature:

With hydrogenchloride; for 4h; Heating;

DOI:10.1021/jm00378a023

Reference yield:

cycloactanone (502-49-8) → methyl 1-aminocyclooctanecarboxylate hydrochloride (92398-52-2)

Guidance literature:

Multi-step reaction with 3 steps

1: ammonium carbonate / aq. ethanol / 55 - 60 °C

2: aq. NaOH / 72 h / Heating

3: HCl / 4 h / Heating

With ammonium carbonate; hydrogenchloride; sodium hydroxide; In ethanol;

DOI:10.1021/ja962905b

Reference yield:

1,3-diazaspiro[4.7]dodecane-2,4-dione (710-94-1) → methyl 1-aminocyclooctanecarboxylate hydrochloride (92398-52-2)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. NaOH / 72 h / Heating

2: HCl / 4 h / Heating

With hydrogenchloride; sodium hydroxide;

DOI:10.1021/ja962905b

upstream raw materials:

methanol

1-aminocyclooctane-1-carboxylic acid

cycloactanone

1,3-diazaspiro[4.7]dodecane-2,4-dione

Downstream raw materials:

methyl 1-({[3'-fluoro-4'-(methyloxy)-3-nitro-4-biphenylyl]carbonyl}amino)cyclooctanecarboxylate

methyl 1-{[(3',4'-difluoro-3-nitro-4-biphenylyl)carbonyl]amino}cyclooctanecarboxylate

methyl 1-({[3-nitro-4'-(methyloxy)-4-biphenylyl]carbonyl}amino)cyclooctanecarboxylate

N-(benzyloxycarbonyl)-β-benzyl-L-aspartyl-α-aminocyclooctanecarboxylic acid methyl ester

Refernces

• 1、 Tsang, Joseph W.,Schmied, Bernhard,Nyfeler, Rolf,Goodman, Murray. "Peptide Sweeteners. 6. Structural Studies on the C-Terminal Amino Acid of L-Aspartyl Dipeptide Sweeteners". . p. 1663 - 1668. Retrieved 2007/10/02.