2-Vinylpyridine

Base Information

• Chemical Name: 2-Vinylpyridine
• CAS No.: 25014-15-7
• Molecular Formula: C7H7N
• Molecular Weight: 315.41
• European Community (EC) Number: 202-879-8,626-300-7
• ICSC Number: 1232
• NSC Number: 118993,18255
• UN Number: 3073
• UNII: DT4UV4NNKX
• DSSTox Substance ID: DTXSID1026667
• Nikkaji Number: J38.336H
• Wikipedia: 2-Vinylpyridine
• Wikidata: Q4596922
• ChEMBL ID: CHEMBL2134875
• Mol file: 25014-15-7.mol

Synonyms:2-vinylpyridine

Chemical Property of 2-Vinylpyridine

Chemical Property:

• Boiling Point: 160.3°Cat760mmHg
• Flash Point: 46.7°C
• PSA: 38.67000
• Density: 0.968g/cm³
• LogP: 4.87290
• XLogP3: 1.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 105.057849228
• Heavy Atom Count: 8
• Complexity: 78.5
• Transport DOT Label: Poison Flammable Liquid Corrosive

Purity/Quality:

98%Min ^*data from raw suppliers

Poly(2-vinylpyridine) analytical standard, average M ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Nitrogen Compounds -> Pyridines
• Canonical SMILES: C=CC1=CC=CC=N1
• Inhalation Risk: No indication can be given about the rate at which a harmful concentration of this substance in the air is reached on evaporation at 20 °C.
• Effects of Short Term Exposure: The substance may cause effects on the skin. This may result in delayed burns. The substance is severely irritating to the eyes and respiratory tract.
• Effects of Long Term Exposure: Repeated or prolonged contact may cause skin sensitization.
• Uses: heterobifunctional, labeled with fluorescein isothiocyanate group and terminal amine reactive NHS group suitable for monitoring PEGulation reactions.

Technology Process of 2-Vinylpyridine

There total 63 articles about 2-Vinylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-ethynylpyridine (1945-84-2) → 2-vinylpyridine (100-69-6,25014-15-7,27476-03-5,329041-71-6)

Guidance literature:

With hydrogen; In toluene; at 20 ℃; for 12h; under 22801.5 Torr; chemoselective reaction; Autoclave;

DOI:10.1021/jacs.5b07521

Reference yield: 92.3%

diethyl-(2-pyridin-2-yl-ethyl)-amine (25877-30-9) → 2-vinylpyridine (100-69-6,25014-15-7,27476-03-5,329041-71-6)

Guidance literature:

Reference yield: 86.0%

pyridine-2-carbaldehyde (1121-60-4) + diazomethyl-trimethyl-silane (18107-18-1) → 2-vinylpyridine (100-69-6,25014-15-7,27476-03-5,329041-71-6)

Guidance literature:

With (IMes)CuCl; triphenylphosphine; isopropyl alcohol; In 1,4-dioxane; diethyl ether; at 60 ℃; for 16h;

DOI:10.1021/jo061781a

upstream raw materials:

α-picoline

formaldehyd

2-Ethylpyridine

2-(2-Hydroxyethyl)pyridine

Downstream raw materials:

phenyl-(2-phenyl-5-pyridin-2-yl-isoxazolidin-3-yl)-methanone

5-benzylidene-3-(2-pyridin-2-yl-ethyl)-thiazolidine-2,4-dione

5-benzylidene-3-(2-pyridin-2-yl-ethyl)-2-thioxo-thiazolidin-4-one

(2-cyclohexyl-5-pyridin-2-yl-isoxazolidin-3-yl)-phenyl-methanone

Refernces

• 1、 Zhang, Yu-Lan,Wang, Gang-Hu,Wu, Yichen,Zhu, Chun-Yin,Wang, Peng. "Construction of α-Amino Azines via Thianthrenation-Enabled Photocatalyzed Hydroarylation of Azine-Substituted Enamides with Arenes". supporting information. p. 8522 - 8526. Retrieved 2021/11/13.
• 2、 -. "Preparation method of 2-vinylpyridine". Paragraph 0064-0121. . Retrieved 2020/12/15.