2-Oxazolidinone, 3-[(3S)-3-hydroxy-3-(2-methyl-5-benzothiazolyl)-1-oxopropyl]-4-methyl-5 -phenyl-, (4S,5R)-

Base Information

Chemical Name:2-Oxazolidinone, 3-[(3S)-3-hydroxy-3-(2-methyl-5-benzothiazolyl)-1-oxopropyl]-4-methyl-5 -phenyl-, (4S,5R)-
CAS No.:924727-12-8
Molecular Formula:C21H20N2O4S
Molecular Weight:396.467
Hs Code.:

Synonyms:3-[3-hydroxy-3-(2-methyl-benzothiazol-5-yl)-propionyl]-4-methyl-5-phenyl-oxazolidin-2-one;

Suppliers and Price of 2-Oxazolidinone, 3-[(3S)-3-hydroxy-3-(2-methyl-5-benzothiazolyl)-1-oxopropyl]-4-methyl-5 -phenyl-, (4S,5R)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-Oxazolidinone, 3-[(3S)-3-hydroxy-3-(2-methyl-5-benzothiazolyl)-1-oxopropyl]-4-methyl-5 -phenyl-, (4S,5R)-

Chemical Property:

PSA：107.97000
LogP:4.07470

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2-Oxazolidinone, 3-[(3S)-3-hydroxy-3-(2-methyl-5-benzothiazolyl)-1-oxopropyl]-4-methyl-5 -phenyl-, (4S,5R)-

There total 1 articles about 2-Oxazolidinone, 3-[(3S)-3-hydroxy-3-(2-methyl-5-benzothiazolyl)-1-oxopropyl]-4-methyl-5 -phenyl-, (4S,5R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.2%

: (4S,5R)-4-methyl-5-phenyl-3-acetyl-2-oxazolidinone

: 20061-46-5
2-methyl-1,3-benzothiazole-5-carbaldehyde

: 924727-12-8
(4S,5R,3'S)-4-methyl-5-phenyl-3-[3'-(2-methylbenzothiazol-5-yl)-3'-hydroxy-2'-oxopropyl]-2-oxazolidinone

: (4S,5R,3'R)-4-methyl-5-phenyl-3-[3'-(2-methylbenzothiazol-5-yl)-3'-hydroxy-2'-oxopropyl]-2-oxazolidinone

: 16251-45-9,17097-67-5,28044-22-6,28044-23-7,39663-75-7,54418-69-8,77943-39-6,125133-96-2,149055-02-7
(4S,5R)-4-methyl-5-phenyl-oxazolidin-2-one

Guidance literature:: With zinc(II) chloride; lithium diisopropyl amide; In tetrahydrofuran; hexane; at -70 ℃; for 1.5h;
DOI:10.1002/anie.200602785

Reference yield:

: 924727-12-8
(4S,5R,3'S)-4-methyl-5-phenyl-3-[3'-(2-methylbenzothiazol-5-yl)-3'-hydroxy-2'-oxopropyl]-2-oxazolidinone

: 18162-48-6
tert-butyldimethylsilyl chloride

: 924727-16-2
(4S,5R,3'S)-4-methyl-5-phenyl-3-[3'-(2-methylbenzothiazol-5-yl)-3'-(tert-butyldimethylsilyloxy)-2'-oxopropyl]-2-oxazolidinone

Guidance literature:: With 1H-imidazole; sodium hydrogencarbonate; In N,N-dimethyl-formamide; at 23 ℃;
DOI:10.1002/anie.200602785

Reference yield:

: 924727-12-8
(4S,5R,3'S)-4-methyl-5-phenyl-3-[3'-(2-methylbenzothiazol-5-yl)-3'-hydroxy-2'-oxopropyl]-2-oxazolidinone

: [(3S)-3-(2-methylbenzothiazol-5-yl)-3-(tert-butyldimethylsilyloxy)-propyl]-triphenylphosphonium iodide

Guidance literature:: Multi-step reaction with 5 steps

1: imidazole; NaHCO₃ / dimethylformamide / 23 °C

2: 99.2 percent / ethanol / 6 h / Heating

3: 97.1 percent / diisobutylaluminum hydride; n-BuLi; isopropanol / toluene; hexane; H₂O / 3 h / 23 °C

4: 90 percent / imidazole; iodine; triphenylphosphine / CH₂Cl₂ / 0.5 h / 23 °C

5: toluene / 18 h / 100 °C

With 1H-imidazole; n-butyllithium; iodine; diisobutylaluminium hydride; sodium hydrogencarbonate; triphenylphosphine; isopropyl alcohol; In ethanol; hexane; dichloromethane; water; N,N-dimethyl-formamide; toluene;
DOI:10.1002/anie.200602785