5-Fluoro-2-nitrobenzeneboronic acid pinacol ester, 96%

Base Information

• Chemical Name: 5-Fluoro-2-nitrobenzeneboronic acid pinacol ester, 96%
• CAS No.: 925207-14-3
• Molecular Formula: C₁₂H₁₅BFNO₄
• Molecular Weight: 267.065
• Mol file: 925207-14-3.mol

Synonyms:

Chemical Property of 5-Fluoro-2-nitrobenzeneboronic acid pinacol ester, 96%

Chemical Property:

• PSA: 64.28000
• LogP: 2.55630

Purity/Quality:

99% ^*data from raw suppliers

2-(5-fluoro-2-nitrophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Fluoro-2-nitrobenzeneboronic acid pinacol ester, 96%

There total 3 articles about 5-Fluoro-2-nitrobenzeneboronic acid pinacol ester, 96% which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

5-fluoro-2-nitrophenyl trifluoromethanesulfonate (722536-31-4) + bis(pinacol)diborane (73183-34-3) → 2-(5-fluoro-2-nitrophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (925207-14-3)

Guidance literature:

With potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; at 80 ℃; for 20h;

DOI:10.1039/b613580n

Reference yield: 45.0%

2-bromo-4-fluoronitrobenzene (700-36-7) + bis(pinacol)diborane (73183-34-3) → 2-(5-fluoro-2-nitrophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (925207-14-3)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; In 1,4-dioxane; Inert atmosphere; Reflux;

DOI:10.1021/jacs.5b02946

Reference yield:

5-fluoro-2-nitrophenol (446-36-6) → 2-(5-fluoro-2-nitrophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (925207-14-3)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / 0 - 20 °C

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / 1,4-dioxane / 80 °C / Inert atmosphere

With pyridine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; In 1,4-dioxane;

upstream raw materials:

5-fluoro-2-nitrophenyl trifluoromethanesulfonate

bis(pinacol)diborane

2-bromo-4-fluoronitrobenzene

5-fluoro-2-nitrophenol