Diethyl 6-fluoroquinoline-2,3-dicarboxylate

Base Information

Chemical Name:Diethyl 6-fluoroquinoline-2,3-dicarboxylate
CAS No.:92525-75-2
Molecular Formula:C₁₅H₁₄FNO₄
Molecular Weight:291.279
Hs Code.:2933499090
DSSTox Substance ID:DTXSID00537947
Wikidata:Q82413125
Mol file:92525-75-2.mol

Synonyms:92525-75-2;6-Fluoroquinoline-2,3-dicarboxylic acid diethyl ester;DIETHYL 6-FLUOROQUINOLINE-2,3-DICARBOXYLATE;diethyl 6-fluoro-2,3-quinolinedicarboxylate;DTXSID00537947;MFCD08669711;AB46019

Suppliers and Price of Diethyl 6-fluoroquinoline-2,3-dicarboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
6-FLUOROQUINOLINE-2,3-DICARBOXYLIC ACID DIETHYL ESTER 95.00%
5MG
$ 496.58

Total 6 raw suppliers

Chemical Property of Diethyl 6-fluoroquinoline-2,3-dicarboxylate

Chemical Property:

Vapor Pressure:8.79E-06mmHg at 25°C
Boiling Point:373.7oC at 760 mmHg
Flash Point:179.8oC
PSA：65.49000
Density:1.267g/cm3
LogP:2.72730
XLogP3:3.1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:6
Exact Mass:291.09068609
Heavy Atom Count:21
Complexity:390

Purity/Quality:

98%min ^*data from raw suppliers

6-FLUOROQUINOLINE-2,3-DICARBOXYLIC ACID DIETHYL ESTER 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C1=C(N=C2C=CC(=CC2=C1)F)C(=O)OCC

Technology Process of Diethyl 6-fluoroquinoline-2,3-dicarboxylate

There total 4 articles about Diethyl 6-fluoroquinoline-2,3-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 395-81-3
5-fluoro-2-nitrobenzaldehyde

: 762-21-0
acetylenedicarboxylic acid diethyl ester

: 92525-75-2
6-Fluoro-quinoline-2,3-dicarboxylic acid diethyl ester

Guidance literature:: With formic acid; at 110 ℃; for 18h; Inert atmosphere;
DOI:10.1016/j.jcat.2020.01.034

Reference yield: 72.0%

: 92525-70-7
6-Fluoro-1-oxy-quinoline-2,3-dicarboxylic acid diethyl ester

: 92525-75-2
6-Fluoro-quinoline-2,3-dicarboxylic acid diethyl ester

Guidance literature:: With phosphorus trichloride; In chloroform; for 3h; Heating;
DOI:10.1021/jo00199a050

Reference yield:

: 7071-15-0
diethyl 2-(diethoxyphosphoryl)succinate

: 92525-75-2
6-Fluoro-quinoline-2,3-dicarboxylic acid diethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 50 percent / NaOEt / ethanol / 1.5 h / ice bath

2: 72 percent / PCl₃ / CHCl₃ / 3 h / Heating

With sodium ethanolate; phosphorus trichloride; In ethanol; chloroform;
DOI:10.1021/jo00199a050