7071-15-0

Usage

Uses

Used in Pharmaceutical Synthesis:
Diethyl 2-diethoxyphosphorylbutanedioate serves as a key intermediate in the production of pharmaceuticals, facilitating the creation of essential medications for treating various health conditions.
Used as an Insecticide:
diethyl 2-diethoxyphosphorylbutanedioate has been studied for its potential use as an insecticide, capitalizing on its properties to control and manage pest populations in agricultural and other settings.
Used as a Precursor in Synthesis:
Diethyl 2-diethoxyphosphorylbutanedioate is utilized as a precursor for the synthesis of other phosphorus-containing compounds, which are vital in a range of industrial applications.
Used in Catalysis of Organic Reactions:
diethyl 2-diethoxyphosphorylbutanedioate has been investigated for its catalytic properties in organic reactions, making it a valuable asset in the field of chemical engineering and synthesis of complex organic molecules.
Used in Medicinal Chemistry Research:
Due to its versatile nature, diethyl 2-diethoxyphosphorylbutanedioate has garnered interest in medicinal chemistry research, where it may contribute to the development of new drugs and therapies.
Used in Chemical Engineering:
Its applications extend to chemical engineering, where diethyl 2-diethoxyphosphorylbutanedioate aids in the advancement of chemical processes and the synthesis of novel compounds with potential industrial and commercial uses.

InChI:InChI=1/C12H23O7P/c1-5-16-11(13)9-10(12(14)17-6-2)20(15,18-7-3)19-8-4/h10H,5-9H2,1-4H3

Upstream product

• 867-13-0 diethoxyphosphoryl-acetic acid ethyl ester 
• 105-39-5 chloroacetic acid ethyl ester 
• 141-05-9 Diethyl maleate 
• 122-52-1 triethyl phosphite 
• 617-48-1 malic acid 
• 7554-12-3 diethylmalate 
• 762-04-9 Diethyl phosphonate 
• 130648-65-6 2-(Diethoxy-phosphoryl)-3-ethoxycarbonyl-succinic acid 1-ethyl ester 
• 105-36-2 ethyl bromoacetate 
• 589-57-1 diethyl phosphorylchloridite 
• 123-25-1 succinic acid diethyl ester 
• 762-04-9 phosphonic acid diethyl ester 
• 1520-50-9 but-2-enedioic acid diethyl ester 
• 130648-77-0 (2,3-dihydro-5-ethoxy-4-ethoxycarbonyl-2-oxofuran-3-ylidene)triethoxyphosphorane 

Downstream Products

• 74531-23-0 ethyl (E)-4-(2-furyl)-3-ethoxycarbonylbut-3-enoate 
• 74531-18-3 ethyl (E)-4-(4-methylphenyl)-3-ethoxycarbonylbut-3-enoate 
• 58195-50-9 ethyl (E)-4-phenyl-3-ethoxycarbonyl-3-enoate 
• 125701-98-6 diethyl (E)-2-(4-methoxybenzylidene)succinate 
• 74531-29-6 Diethyl-1-benzyl-2-imidazolyl-methylensuccinat 
• 289622-32-8 6,7-methylenedioxy-1-(3,4-dimethoxyphenyl)naphthalene-2,3-dicarboxylic acid 2-ethyl ester 
• 289622-27-1 diethyl 6,7-methylenedioxy-1-(3,4-dimethoxyphenyl)naphthalene-2,3-dicarboxylate 
• 5768-48-9 1-phosphonoethane-1,2-dicarboxylic acid 
• 202201-20-5 (2-Benzoyl-1-[1,3]dithiolan-2-ylidene-3,3-bis-ethylsulfanyl-allyl)-phosphonic acid diethyl ester 
• 202201-19-2 [2-Benzoyl-1-(bis-ethylsulfanyl-methylene)-3,3-bis-ethylsulfanyl-allyl]-phosphonic acid diethyl ester 
• 74531-20-7 diethyl (Z)-2-(4-chlorobenzylidene)succinate 
• 74531-38-7 1-Benzyl-5(1H)-oxoimidazo<1,2-a>pyridin-7-carbonsaeure-ethylester 
• 74531-20-7 ethyl (E)-4-(4-chlorophenyl)-3-ethoxycarbonylbut-3-enoate 
• 92525-74-1 diethyl 6-chloroquinoline-2,3-dicarboxylate 

Relevant academic research and scientific papers

Preparation method of phosphine series reactive flame retardant monomer

The invention provides a preparation method of a phosphine series reactive flame retardant monomer. The preparation method comprises the following steps: preparing a compound with a structure shown ina formula VI or a formula VII; under the action of alkaline solution, hydrolyzing the compound with the structure shown in the formula VI or the formula VII, then adding acid solution to regulate acid, then adding inorganic salt to carry out saturation processing, then adding an organic solvent to extract, and then performing evaporation drying on the organic solvent to obtain a compound with a structure shown in a formula VIII or a formula IX; adding a dehydrating agent into the compound with the structure shown in the formula VIII or the formula IX to enable the compound with the structureshown in the formula VIII or the formula IX to be dewatered and cyclized so as to obtain the phosphine series reactive flame retardant monomer with a structure shown in a formula I or a formula II. The preparation method of the phosphine series reactive flame retardant monomer, which is provided by the invention, is simple in process, high in reaction yield and simple and convenient to operate, does not need to use special equipment, is sufficient and reliable in source of raw materials, low in cost, environmentally friendly and suitable for industrial production.

Novel fatty acid synthase (FAS) inhibitors: Design, synthesis, biological evaluation, and molecular docking studies

Several novel series of C75 derivatives were synthesized and evaluated for their FAS inhibitory activities. The results showed compound 4-methylene-2-octyl-5-oxo-tetrahydro-thiophene-3-carboxylic acid (1c) had more effective FAS inhibitory (IC50 was 2.56 μM and T.I. was 9.26) and potent anti-tumor activities on HL60 and Hela cells in vitro (IC50 were 5.38 μM and 46.10 μM, respectively).

Metal complexes of ethane and propane frame-substituted oligophosphonic and oligophosphonocarboxylic acids

The stability constants of the complexes of one oligophosphonic acid (ethane-1,1,2-triphosphonic acid 1), five phosphonocarboxylic acids (ethane-1,2-diphospho-no-1-carboxylic acid 2, propane-1,1-diphosphono-2,3- dicarboxylic acid 3, ethane-1,2-diphosphono-1,2-dicarboxylic acid 4, ethane-1-phosphono-1,2-dicarboxylic acid 5, and propane-1-phosphono-1,2,3- tricarboxylic acid 6), and ethane-1,1,2-tricarboxylic acid 7 with Cu2 +, Ni2 +, Zn2 +, Cd2 + and Ca2 + were determined by pH-metric titrations. The six ligands of type HNL (N = 4 - 6) form mononuclear MLHn (n = 0, 1, , N-1) complexes with chelate structure. The calcium complexes seem to be less stable than the transition metal complexes.

Transformations of electrophilic reagents in a diethyl phosphite-potassium carbonate-ethanol system

Transformations of alkyl halides, aldehydes, and activated alkenes in a (EtO)2PHO-K2CO3-EtOH heterophase system were studied. The reactions are catalyzed by EtOK that formed and follow the known schemes of the interaction of hydrophosphoryl compounds with electrophiles.

2-Phosphono-1,1,4,4-tetrathio-1,3-butadienes. Synthesis and synthetic application to highly functionalized dienes and heterocycles

A wide variety of 2-phosphono-1,1,4,4-tetrathio-1,3-butadienes (i.e. phosphonobisketene tetrathioacetals) was first synthesized from tetraethyl 2-phosphonosuccinate and thiols in the presence of organoaluminum reagent.The phosphonobisketene tetrathioaceta

A CONVENIENT PREPARATION OF α-PHOSPHONO ESTERS AND LACTONES VIA C-P BOND FORMATION

The reaction of ester and lactone enolates with diethyl phosphorochloridite, followed by air oxidation of the immediate reaction products, has proven to be a general alternative to the traditional Arbuzov synthesis of α-phosphono esters and lactones.

Reactions of Ylides formed from Trialkyl Phosphites with Dialkyl Acetylenedicarboxylates in the Presence of Carbon Dioxide

The ylides (2)(3) formed from trialkyl phosphites and dialkyl acetylenedicarboxylates in the presence of carbon dioxide react with proton donors, such as phenol or diethylamine, to give stabilised ylides (4).With water, proton transfer within the stabilised ylide results in the formation of a quasiphosphonium salt (6) which can then cyclise to a 1,2-oxaphospholane (7) or dealkylate to give phosphonates (5).In some cases, hydrolysis of the ylide (2)(3) occurs to give phosphate and an acid (9).The formation of a furan (12) during the reaction of the ylide (2)(3) with 4-nitrobenzaldehyde has been investigated.

Synthesis of Phosphonic Acid Esters in Solid-Liquid Catalytic Two-Phase System

Alkylation of dialkyl phosphite anions and their addition to electrophilic alkenes can be efficiently carried out in the presence of anhydrous K2CO3 and tetraalkylammonium or crown ether catalysts (solid-liquid catalytic two-phase systems).