(1S)-1,2,3,4-Tetrahydro-8-methoxy-1alpha,3beta-dimethyl-5-[(aR)-4,5-dimethoxy-2-methyl-1-naphthalenyl]isoquinoline-6-ol

Base Information

Chemical Name:(1S)-1,2,3,4-Tetrahydro-8-methoxy-1alpha,3beta-dimethyl-5-[(aR)-4,5-dimethoxy-2-methyl-1-naphthalenyl]isoquinoline-6-ol
CAS No.:32221-59-3
Molecular Formula:C₂₅H₂₉NO₄
Molecular Weight:407.51
Hs Code.:
Wikidata:Q105342243
Mol file:32221-59-3.mol

Synonyms:(1S)-1,2,3,4-Tetrahydro-8-methoxy-1alpha,3beta-dimethyl-5-[(aR)-4,5-dimethoxy-2-methyl-1-naphthalenyl]isoquinoline-6-ol;FT-0701062

Suppliers and Price of (1S)-1,2,3,4-Tetrahydro-8-methoxy-1alpha,3beta-dimethyl-5-[(aR)-4,5-dimethoxy-2-methyl-1-naphthalenyl]isoquinoline-6-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of (1S)-1,2,3,4-Tetrahydro-8-methoxy-1alpha,3beta-dimethyl-5-[(aR)-4,5-dimethoxy-2-methyl-1-naphthalenyl]isoquinoline-6-ol

Chemical Property:

Vapor Pressure:2.2E-13mmHg at 25°C
Boiling Point:565.3°Cat760mmHg
Flash Point:295.7°C
PSA：59.95000
Density:1.137g/cm³
LogP:5.47060
XLogP3:5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:407.20965841
Heavy Atom Count:30
Complexity:573

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1CC2=C(C(=CC(=C2C(N1)C)OC)O)C3=C4C=CC=C(C4=C(C=C3C)OC)OC

Technology Process of (1S)-1,2,3,4-Tetrahydro-8-methoxy-1alpha,3beta-dimethyl-5-[(aR)-4,5-dimethoxy-2-methyl-1-naphthalenyl]isoquinoline-6-ol

There total 14 articles about (1S)-1,2,3,4-Tetrahydro-8-methoxy-1alpha,3beta-dimethyl-5-[(aR)-4,5-dimethoxy-2-methyl-1-naphthalenyl]isoquinoline-6-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

: 36209-87-7,139164-66-2
(-)-ancistrocladinine

: 32221-59-3,36209-88-8,56688-90-5,57030-01-0
isoancistrocladine

Guidance literature:: With sodium tetrahydroborate; In methanol; at 0 ℃;
DOI:10.1016/0031-9422(92)83505-S

Reference yield:

: 104292-16-2,104371-25-7
(1S,3S)-2-Benzyl-5-(4,5-dimethoxy-2-methyl-naphthalen-1-yl)-8-methoxy-1,3-dimethyl-1,2,3,4-tetrahydro-isoquinolin-6-ol

: 32221-59-3,36209-88-8,56688-90-5,57030-01-0
ancistrocladine

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; Yield given;

Reference yield:

: 18917-77-6
(3,5-dimethoxyphenyl)acetone

: 32221-59-3,36209-88-8,56688-90-5,57030-01-0
ancistrocladine

Guidance literature:: Multi-step reaction with 10 steps

1: 1) H₂; 2) H₂ / 1) Ranay-Ni W₂; 2) 10percent Pd/C / 1.) toluene, ethanol, heating, 5 bar, 80 h; 2) MeOH, 5 bar 120 h

2: 1) NEt₃; 2) POCl₃ / 1) CH₂Cl₂; 2) MeCN, reflux

3: 85 percent / LiAlH₄/AlMe₃ / tetrahydrofuran / 3 h / -78 - 0 °C

4: K₂CO₃ / propan-1-ol / Heating

5: 47 percent HBr / 9 h / 70 °C

6: 86 percent / NEt₃, 4-N,N-dimethylaminopyridine / CH₂Cl₂

7: 49 percent / Pd(PPh₃)2Cl₂, NaOAc, N,N-dimethylacetamide / 100 °C

8: 95 percent / LiAlH₄ / tetrahydrofuran

9: 1) CCl₂Br-CCl₂Br/polym. PPh₃; 2) LiAlH₄ / 1) CH₂Cl₂; 2) THF

10: H₂ / 10 percent Pd/C / methanol

With dmap; bis-triphenylphosphine-palladium(II) chloride; lithium aluminium tetrahydride; 1,2-dibromo-1,1,2,2-tetrachloroethane; N,N-dimethyl acetamide; polym. PPh₃; hydrogen bromide; hydrogen; trimethylaluminum; sodium acetate; potassium carbonate; triethylamine; trichlorophosphate; palladium on activated charcoal; nickel; In tetrahydrofuran; methanol; propan-1-ol; dichloromethane;