(3,5-DIMETHOXYPHENYL)ACETONE

Base Information

• Chemical Name: (3,5-DIMETHOXYPHENYL)ACETONE
• CAS No.: 18917-77-6
• Molecular Formula: C11H14O3
• Molecular Weight: 194.23
• Hs Code.: 2914509090
• Mol file: 18917-77-6.mol

Synonyms:1-(3,5-Dimethoxyphenyl)acetone;3,5-Dimethoxybenzylmethyl ketone;(3,5-Dimethoxy-phenyl)-aceton;1-(3,5-dimethoxyphenyl)-2-propanone;(3,5-dimethoxyphenyl)acetone;

Chemical Property of (3,5-DIMETHOXYPHENYL)ACETONE

Chemical Property:

• PSA: 35.53000
• LogP: 1.83530

Purity/Quality:

99%min ^*data from raw suppliers

1-(3,5-Dimethoxyphenyl)propan-2-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (3,5-DIMETHOXYPHENYL)ACETONE

There total 16 articles about (3,5-DIMETHOXYPHENYL)ACETONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

methyl iodide (74-88-4) + 4-hydroxy-benzoic acid (99-96-7) → (3,5-dimethoxyphenyl)acetone (18917-77-6)

Guidance literature:

With potassium carbonate; In acetone; at 20 ℃;

DOI:10.3390/molecules25174003

Reference yield: 90.0%

1,3-dimethoxy-5-(2-nitroprop-1-en-1-yl)benzene (18917-76-5) → (3,5-dimethoxyphenyl)acetone (18917-77-6)

Guidance literature:

With iron; acetic acid; for 3h; Heating;

DOI:10.1002/jhet.5570330460

Reference yield: 90.0%

1-chloro-3,5-dimethoxybenzene (7051-16-3) + acetone (67-64-1) → (3,5-dimethoxyphenyl)acetone (18917-77-6)

Guidance literature:

With bis[chloro(1,2,3-trihapto-allylbenzene)palladium(II)]; 2-methoxy-6-(N-methyl-N-phenyl-amino)phenyl(dicyclohexyl)phosphine; caesium carbonate; at 90 ℃; for 12h; Inert atmosphere; Schlenk technique; Sealed tube;

DOI:10.1002/adsc.201300207

upstream raw materials:

(3,5-dimethoxyphenyl)acetic acid

methyllithium

ethanol

2-(3,5-dimethoxyphenyl)acetyl chloride

Downstream raw materials:

3-((S)-2-Benzylamino-propyl)-5-methoxy-phenol

(2S)-1-(3',5'-dimethoxyphenyl)-2-aminopropane

(1R)-2-(3,5-dimethoxyphenyl)-1-methylethylamine

(R)-N-<1-(3,5-dimethoxyphenyl)-2-propylidene>-α-methylbenzenemethanamine

Refernces

• 1、 Fragis, Meghan,Deobald, Jackson L.,Dharavath, Srinivas,Scott, Jeffrey,Magolan, Jakob. "Aldehyde to Ketone Homologation Enabled by Improved Access to Thioalkyl Phosphonium Salts". supporting information. p. 4548 - 4552. Retrieved 2021/06/28.
• 2、 Huang, Haizhou,Liu, Xiaoyan,Zhou, Le,Chang, Mingxin,Zhang, Xumu. "Direct Asymmetric Reductive Amination for the Synthesis of Chiral β-Arylamines". supporting information. p. 5309 - 5312. Retrieved 2016/04/26.