Ethanimidic acid, 2,2,2-trichloro-, 1,1'-[(1R,2R)-1-[4,5-dimethoxy-3-methyl-2-(2-propen-1-yloxy)phenyl]-2-[ [(1,1-dimethylethoxy)carbonyl]amino]-1,3-propanediyl] ester

Base Information

Chemical Name:Ethanimidic acid, 2,2,2-trichloro-, 1,1'-[(1R,2R)-1-[4,5-dimethoxy-3-methyl-2-(2-propen-1-yloxy)phenyl]-2-[ [(1,1-dimethylethoxy)carbonyl]amino]-1,3-propanediyl] ester
CAS No.:925703-64-6
Molecular Formula:C24H31Cl6N3O7
Molecular Weight:686.244
Hs Code.:

Ethanimidic acid, 2,2,2-trichloro-,
1,1'-[(1R,2R)-1-[4,5-dimethoxy-3-methyl-2-(2-propen-1-yloxy)phenyl]-2-[
[(1,1-dimethylethoxy)carbonyl]amino]-1,3-propanediyl] ester

Synonyms:

Suppliers and Price of Ethanimidic acid, 2,2,2-trichloro-, 1,1'-[(1R,2R)-1-[4,5-dimethoxy-3-methyl-2-(2-propen-1-yloxy)phenyl]-2-[ [(1,1-dimethylethoxy)carbonyl]amino]-1,3-propanediyl] ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Ethanimidic acid, 2,2,2-trichloro-, 1,1'-[(1R,2R)-1-[4,5-dimethoxy-3-methyl-2-(2-propen-1-yloxy)phenyl]-2-[ [(1,1-dimethylethoxy)carbonyl]amino]-1,3-propanediyl] ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Ethanimidic acid, 2,2,2-trichloro-, 1,1'-[(1R,2R)-1-[4,5-dimethoxy-3-methyl-2-(2-propen-1-yloxy)phenyl]-2-[ [(1,1-dimethylethoxy)carbonyl]amino]-1,3-propanediyl] ester

There total 5 articles about Ethanimidic acid, 2,2,2-trichloro-, 1,1'-[(1R,2R)-1-[4,5-dimethoxy-3-methyl-2-(2-propen-1-yloxy)phenyl]-2-[ [(1,1-dimethylethoxy)carbonyl]amino]-1,3-propanediyl] ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 925704-02-5
tert-butyl (1R,2R)-1-(2-allyloxy-4,5-dimethoxy-3-methylphenyl)-1,3-dihydroxypropan-2-ylcarbamate

: 545-06-2
trichloroacetonitrile

: 925703-64-6
(1R,2R)-1-(2-allyloxy-4,5-dimethoxy-3-methylphenyl)-2-(tert-butoxycarbonylamino)propane-1,3-diyl bis(2,2,2-trichloroacetimidate)

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; at 0 - 20 ℃; for 1h;
DOI:10.1021/ol0627202

Reference yield:

: 925703-89-5
tert-butyl (R)-4-((R)-hydroxy(2-hydroxy-4,5-dimethoxy-3-methylphenyl)methyl)-2,2-dimethyloxazolidine-3-carboxylate

: 925703-64-6
(1R,2R)-1-(2-allyloxy-4,5-dimethoxy-3-methylphenyl)-2-(tert-butoxycarbonylamino)propane-1,3-diyl bis(2,2,2-trichloroacetimidate)

Guidance literature:: Multi-step reaction with 3 steps

1: K₂CO₃; NaI / acetone / 16 h / 20 °C

2: p-toluenesulfonic acid / methanol / 2 h / 0 °C

3: 50 percent / DBU / CH₂Cl₂ / 1 h / 0 - 20 °C

With potassium carbonate; toluene-4-sulfonic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; sodium iodide; In methanol; dichloromethane; acetone;
DOI:10.1021/ol0627202

Reference yield:

: 4-[(2-allyloxy-4,5-dimethoxy-3-methyl-phenyl)-hydroxy-methyl]-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

: 925703-64-6
(1R,2R)-1-(2-allyloxy-4,5-dimethoxy-3-methylphenyl)-2-(tert-butoxycarbonylamino)propane-1,3-diyl bis(2,2,2-trichloroacetimidate)

Guidance literature:: Multi-step reaction with 2 steps

1: p-toluenesulfonic acid / methanol / 2 h / 0 °C

2: 50 percent / DBU / CH₂Cl₂ / 1 h / 0 - 20 °C

With toluene-4-sulfonic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; In methanol; dichloromethane;
DOI:10.1021/ol0627202