Hexanamide, 6-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-N-[(1S,2S)-2-hydroxy-1-methyl-2 -phenylethyl]-N,2-dimethyl-, (2R)-

Base Information

Chemical Name:Hexanamide, 6-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-N-[(1S,2S)-2-hydroxy-1-methyl-2 -phenylethyl]-N,2-dimethyl-, (2R)-
CAS No.:926035-76-9
Molecular Formula:C23H41NO3Si
Molecular Weight:407.669
Hs Code.:

Synonyms:

Suppliers and Price of Hexanamide, 6-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-N-[(1S,2S)-2-hydroxy-1-methyl-2 -phenylethyl]-N,2-dimethyl-, (2R)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Hexanamide, 6-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-N-[(1S,2S)-2-hydroxy-1-methyl-2 -phenylethyl]-N,2-dimethyl-, (2R)-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Hexanamide, 6-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-N-[(1S,2S)-2-hydroxy-1-methyl-2 -phenylethyl]-N,2-dimethyl-, (2R)-

There total 1 articles about Hexanamide, 6-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-N-[(1S,2S)-2-hydroxy-1-methyl-2 -phenylethyl]-N,2-dimethyl-, (2R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 92511-12-1
1-{[dimethyl(1,1-dimethylethyl)silyl]oxy}-4-iodobutane

: 159213-03-3
N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N-methylpropionamide

: 926035-76-9
C₂₃H₄₁NO₃Si

Guidance literature:: N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N-methylpropionamide; With lithium chloride; lithium diisopropyl amide; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 1.5h;

1-{[dimethyl(1,1-dimethylethyl)silyl]oxy}-4-iodobutane; In tetrahydrofuran; hexane; at 20 ℃; Further stages.;
DOI:10.1021/ol062834d

Reference yield:

: 926035-76-9
C₂₃H₄₁NO₃Si

: C₉H₁₅O₂P(C₆H₅)3⁽¹⁺⁾*Br^(1-)

Guidance literature:: Multi-step reaction with 7 steps

1.1: 86 percent / Li(H₂N)BH₃ / tetrahydrofuran; hexane / 2 h / 20 °C

2.1: 82 percent / (COCl)2; DMSO; triethylamine / CH₂Cl₂ / 0.33 h / -30 °C

3.1: NaH / tetrahydrofuran; various solvent(s) / 0 °C

3.2: 84 g / tetrahydrofuran; various solvent(s) / 4 h / 0 °C

4.1: 88 percent / Dibal-H / hexane / 0.5 h / -78 °C

5.1: 87 percent / CBr₄; triphenylphosphine / CH₂Cl₂ / 0.17 h / cooling

6.1: 82 percent / Jones reagent / acetone / 2 h

7.1: 85 percent / acetonitrile / 8 h / Heating

With jones reagent; oxalyl dichloride; carbon tetrabromide; sodium hydride; diisobutylaluminium hydride; dimethyl sulfoxide; triethylamine; triphenylphosphine; In tetrahydrofuran; hexane; dichloromethane; acetone; acetonitrile; 2.1: Swern oxidation / 6.1: Jones oxidation;
DOI:10.1021/ol062834d