15(S)-Hydroxy-(5Z,8Z,11Z,13E)-*eicosatet raenoic aci

Base Information

Chemical Name:15(S)-Hydroxy-(5Z,8Z,11Z,13E)-*eicosatet raenoic aci
CAS No.:70946-44-0
Molecular Formula:C₂₁H₃₄O₃
Molecular Weight:334.499
Hs Code.:
DSSTox Substance ID:DTXSID401169849
ChEMBL ID:CHEMBL3349313

Synonyms:15-HETE methyl ester;15-hydroxy-5,8,11,13 eicosatetraenoic acid methyl ester

Suppliers and Price of 15(S)-Hydroxy-(5Z,8Z,11Z,13E)-*eicosatet raenoic aci

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Cayman Chemical
15(S)-HETE methyl ester ≥98%
100μg
$ 310.00

Cayman Chemical
15(S)-HETE methyl ester ≥98%
50μg
$ 163.00

Cayman Chemical
15(S)-HETE methyl ester ≥98%
25μg
$ 86.00

Total 6 raw suppliers

Chemical Property of 15(S)-Hydroxy-(5Z,8Z,11Z,13E)-*eicosatet raenoic aci

Chemical Property:

Vapor Pressure:6.75E-10mmHg at 25°C
Boiling Point:447.7°C at 760 mmHg
Flash Point:169.9°C
PSA：46.53000
Density:0.952g/cm³
LogP:5.27590
XLogP3:5.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:15
Exact Mass:334.25079494
Heavy Atom Count:24
Complexity:405

Purity/Quality:

99% ^*data from raw suppliers

15(S)-HETE methyl ester ≥98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCCCCC(C=CC=CCC=CCC=CCCCC(=O)OC)O
Isomeric SMILES:CCCCC[C@@H](/C=C/C=C\C/C=C\C/C=C\CCCC(=O)OC)O
Description 15(S)-HETE methyl ester is a synthetic derivative of 15(S)-HETE , a major arachidonic acid metabolite from the 15-lipoxygenase pathway. Methyl esters of lipids are commonly used in formulations of nutritional supplements.

Technology Process of 15(S)-Hydroxy-(5Z,8Z,11Z,13E)-*eicosatet raenoic aci

There total 14 articles about 15(S)-Hydroxy-(5Z,8Z,11Z,13E)-*eicosatet raenoic aci which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 97643-28-2
(5Z,8Z,11Z,13E)-(S)-15-(tert-Butyl-dimethyl-silanyloxy)-icosa-5,8,11,13-tetraenoic acid methyl ester

: 70946-44-0
(5Z,8Z,11Z,13E,15S)-15-hydroxy-5,8,11,13-eicosatetraenoic acid methyl ester

Guidance literature:: With pyridine hydrogenfluoride; In tetrahydrofuran; at 0 - 25 ℃;
DOI:10.1039/c39850001580

Reference yield: 8.0%

: 186581-53-3,908094-01-9,334-88-3
diazomethane

: 54845-95-3,73945-47-8,83603-31-0
icomucret

: methyl (5Z,8Z,13E)-11,12-trans-epoxy-15-hydroxy-5,8,13-eicosatrienoate

: 70946-44-0
(5Z,8Z,11Z,13E,15S)-15-hydroxy-5,8,11,13-eicosatetraenoic acid methyl ester

: 119008-09-2
(2E,4S)-4-hydroxy-2-nonenal

Guidance literature:: icomucret; With ammonium iron (II) sulfate; ethylenediaminetetraacetic acid; dihydrogen peroxide; phosphate buffer; In chloroform; for 1h; pH=7.4;

diazomethane; In diethyl ether; ethyl acetate; for 0.25h;
DOI:10.1016/j.chemphyslip.2006.02.015

Reference yield:

: 70981-96-3
(5Z,8Z,11Z,13E)-15(S)-hydroperoxyeicosa-5,8,11,13-tetraenoic acid

: 70946-44-0
(5Z,8Z,11Z,13E,15S)-15-hydroxy-5,8,11,13-eicosatetraenoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: PPh₃ / diethyl ether / 0 °C

2: diethyl ether

With triphenylphosphine; In diethyl ether;
DOI:10.1021/jo960239r