Icomucret

Base Information

Chemical Name:Icomucret
CAS No.:54845-95-3
Molecular Formula:C20H32O3
Molecular Weight:320.472
Hs Code.:2918199090
European Community (EC) Number:688-204-1
UNII:44JHK6G39Q
ChEMBL ID:CHEMBL594621
DSSTox Substance ID:DTXSID101031956
Metabolomics Workbench ID:2628
NCI Thesaurus Code:C80608
Nikkaji Number:J303.917J
Pharos Ligand ID:6QVFLKU7BC85
Wikidata:Q21099561
Wikipedia:15-Hydroxyeicosatetraenoic_acid
Mol file:54845-95-3.mol

Synonyms:15-HETE;15-hydroxy-5,8,11,13-eicosatetraenoic acid;15-hydroxy-5,8,11,13-eicosatetraenoic acid, (S-(E,Z,Z,Z))-isomer

Suppliers and Price of Icomucret

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
15(S)-HETE
2.5mg
$ 1155.00

TRC
15(S)-HETE
1mg
$ 525.00

Sigma-Aldrich
15(S)-Hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoic acid ~150?μg/mL in ethanol, ≥97.0% (HPLC)
0.1 mg
$ 511.00

Sigma-Aldrich
15(S)-Hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoic acid ~150μg/mL in ethanol, ≥97.0% (HPLC)
.1mg
$ 493.00

Cayman Chemical
15(S)-HETE MaxSpec? Standard ≥95%
100μg
$ 158.00

Cayman Chemical
15(S)-HETE ≥98%
100μg
$ 107.00

Cayman Chemical
15(S)-HETE ≥98%
50μg
$ 58.00

Cayman Chemical
15(S)-HETE ≥98%
25μg
$ 34.00

Cayman Chemical
15(S)-HETE ≥98%
500μg
$ 503.00

American Custom Chemicals Corporation
15-(S)-HYDROXYEICOSATETRAENOIC ACID 95.00%
5MG
$ 497.26

Total 14 raw suppliers

Chemical Property of Icomucret

Chemical Property:

Vapor Pressure:1.48E-11mmHg at 25°C
Refractive Index:1.513
Boiling Point:487.7 °C at 760 mmHg
PKA:4.75±0.10(Predicted)
Flash Point:262.8 °C
PSA：57.53000
Density:0.984 g/cm³
LogP:5.18750
Storage Temp.:−20°C
XLogP3:5.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:14
Exact Mass:320.23514488
Heavy Atom Count:23
Complexity:392

Purity/Quality:

98%,99%, ^*data from raw suppliers

15(S)-HETE ^*data from reagent suppliers

Safty Information:

Pictogram(s): F,Xi
Hazard Codes:F,Xi
Statements: 11-36/37/38
Safety Statements: 7-16-26-36

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCCCCC(C=CC=CCC=CCC=CCCCC(=O)O)O
Isomeric SMILES:CCCCC[C@@H](/C=C/C=C\C/C=C\C/C=C\CCCC(=O)O)O
Description 15(S)-HETE is a major arachidonic acid metabolite from the 15-lipoxygenase pathway. In mammals, 15(S)-HETE is synthesized in the respiratory epithelium, leukocytes, and reticulocytes. 15(S)-HETE is present in μg/ml concentrations in the nasal secretions of allergic rhinitis.
Uses 15(S)-HETE is a major arachidonic acid metabolite from the 15-lipoxygenase pathway. In mammals, 15(S)-HETE is synthesized in the respiratory epithelium, leukocytes, and reticulocytes. 15(S)-HETE is present in μg/ml concentrations in the nasal secretions of allergic rhinitis. 15(S)-HETE is an arachidonic acid metabolite with immunosuppressive activity.

Technology Process of Icomucret

There total 18 articles about Icomucret which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 70946-44-0
(5Z,8Z,11Z,13E,15S)-15-hydroxy-5,8,11,13-eicosatetraenoic acid methyl ester

: 54845-95-3,73945-47-8,83603-31-0
icomucret

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; water; at 25 ℃;
DOI:10.1039/c39850001580

Reference yield: 80.0%

: 70981-96-3
(5Z,8Z,11Z,13E)-15(S)-hydroperoxyeicosa-5,8,11,13-tetraenoic acid

: 54845-95-3,73945-47-8,83603-31-0
icomucret

Guidance literature:: With sodium tetrahydroborate;
DOI:10.1021/jm00385a005

Reference yield:

: 506-32-1,236743-58-1
all cis 5,8,11,14-eicosatetraenoic acid

: 54397-83-0,59985-28-3
12-hydroxyeicosatetraenoic acid

: 82337-46-0
(R)-12-HETE

: 98462-03-4,79495-84-4
8(S)-hydroxyeicosatetraenoic acid

: 105500-09-2,79495-84-4
(8R)-hydroxyeicosatetraenoic acid

: 73347-43-0,73804-65-6
(R)-11-hydroxy-eicosa-5,8,12,14-tetraenoic acid

: 54845-95-3,73945-47-8,83603-31-0
icomucret

: 73945-47-8,83603-31-0
15(R)-HETE

: 54886-50-9,73804-65-6
(S)-11-hydroxy-eicosa-5,8,12,14-tetraenoic acid

Guidance literature:: all cis 5,8,11,14-eicosatetraenoic acid; With 8R-lipoxygenase A₅₈₉M mutant; sodium chloride; calcium chloride; In ethanol; at 20 ℃; pH=8; Enzymatic reaction;

With triphenylphosphine; In methanol; at 20 ℃; for 0.5h; Reagent/catalyst; Kinetics;
DOI:10.1074/jbc.M114.599662