Toxoflavin

Base Information

Chemical Name:Toxoflavin
CAS No.:84-82-2
Molecular Formula:C₇H₇N₅O₂
Molecular Weight:193.165
Hs Code.:2933990090
European Community (EC) Number:687-162-1
NSC Number:67078
UNII:5N5YI4IP1P
DSSTox Substance ID:DTXSID00861658
Nikkaji Number:J4.901H
Wikipedia:Toxoflavin
Wikidata:Q753328
Pharos Ligand ID:J5FF21HX2RQD
Metabolomics Workbench ID:114762
ChEMBL ID:CHEMBL578512
Mol file:84-82-2.mol

Synonyms:1,6-dimethylpyrimido(5,4-E)-as- triazine-5,7(1H,6H)-dione;toxoflavin;xanthothricin

Suppliers and Price of Toxoflavin

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
PKF118-310
100mg
$ 1320.00

Sigma-Aldrich
PKF118-310 ≥98% (HPLC)
5mg
$ 135.00

Sigma-Aldrich
PKF118-310 ≥98% (HPLC)
25mg
$ 541.00

DC Chemicals
Toxoflavin(PKF118-310) >98%
1 g
$ 1600.00

DC Chemicals
Toxoflavin(PKF118-310) >98%
100 mg
$ 500.00

ChemScene
Toxoflavin 99.36%
5mg
$ 110.00

ChemScene
Toxoflavin 99.36%
10mg
$ 190.00

ChemScene
Toxoflavin 99.36%
25mg
$ 390.00

Cayman Chemical
PKF118-310 ≥98%
10mg
$ 208.00

Cayman Chemical
PKF118-310 ≥98%
5mg
$ 110.00

Total 19 raw suppliers

Chemical Property of Toxoflavin

Chemical Property:

Vapor Pressure:0.00473mmHg at 25°C
Melting Point:165 °C
Refractive Index:1.76
Boiling Point:276.7 °C at 760 mmHg
PKA:-2.71±0.20(Predicted)
Flash Point:121.1 °C
PSA：82.67000
Density:1.65 g/cm³
LogP:-1.57780
Storage Temp.:2-8°C
Solubility.:H2O: soluble10mg/mL, clear
XLogP3:-0.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:0
Exact Mass:193.05997448
Heavy Atom Count:14
Complexity:408

Purity/Quality:

98%,99%, ^*data from raw suppliers

PKF118-310 ^*data from reagent suppliers

Safty Information:

Pictogram(s): T
Hazard Codes:T
Statements: 28
Safety Statements: 45-46

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN1C2=NC(=O)N(C(=O)C2=NC=N1)C
Uses Toxoflavin is a distinctive yellow pigment produced by some species of Pseudomonas and Streptomyces. Toxoflavin is one of two toxins produced when a fermented coconut drink, Tempe bonkrek, is contaminated with P. cocovenenans. Toxoflavin (PKF 118-310) is a potent antagonist of Tcf4/b-catenin signalling, inhibiting the expression of survivin and inducing apoptosis in several tumour cell lines. PKF118-310 is an inhibitor of survivin expression and antagonist of Tcf4/b-catenin signaling.

Technology Process of Toxoflavin

There total 19 articles about Toxoflavin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%