N-((1-Ethyl-2-pyrrolidinyl)methyl)-2-methoxy-4-chloro-5-((methylsulfamoyl)amino)benzamide

Base Information

Chemical Name:N-((1-Ethyl-2-pyrrolidinyl)methyl)-2-methoxy-4-chloro-5-((methylsulfamoyl)amino)benzamide
CAS No.:90763-32-9
Molecular Formula:C16H25ClN4O4S
Molecular Weight:404.9121
Hs Code.:
DSSTox Substance ID:DTXSID00920178
ChEMBL ID:CHEMBL14561

Synonyms:BRN 5638031;N-((1-Ethyl-2-pyrrolidinyl)methyl)-2-methoxy-4-chloro-5-((methylsulfamoyl)amino)benzamide;90763-32-9;Benzamide, 4-chloro-N-((1-ethyl-2-pyrrolidinyl)methyl)-2-methoxy-5-(((methylamino)sulfonyl)amino)-;C16H25ClN4O4S;CHEMBL14561;DTXSID00920178;LS-26091;4-Chloro-N-[(1-ethylpyrrolidin-2-yl)methyl]-2-methoxy-5-[(methylsulfamoyl)amino]benzene-1-carboximidic acid

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Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-((1-Ethyl-2-pyrrolidinyl)methyl)-2-methoxy-4-chloro-5-((methylsulfamoyl)amino)benzamide

Chemical Property:

Density:1.312g/cm³
XLogP3:1.3
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:8
Exact Mass:404.1285042
Heavy Atom Count:26
Complexity:571

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCN1CCCC1CNC(=O)C2=CC(=C(C=C2OC)Cl)NS(=O)(=O)NC

Technology Process of N-((1-Ethyl-2-pyrrolidinyl)methyl)-2-methoxy-4-chloro-5-((methylsulfamoyl)amino)benzamide

There total 5 articles about N-((1-Ethyl-2-pyrrolidinyl)methyl)-2-methoxy-4-chloro-5-((methylsulfamoyl)amino)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 10438-96-7
N-methylsulfamoyl chloride

: 68255-79-8
N-<(1-ethyl-2-pyrrolidinyl)methyl>-2-methoxy-4-chloro-5-aminobenzamide

: 90763-32-9
N-<(1-ethyl-2-pyrrolidinyl)methyl>-2-methoxy-4-chloro-5-<(methylsulfamoyl)amino>benzamide

Guidance literature:: With triethylamine; In dichloromethane; for 0.25h;
DOI:10.1021/jm00375a009

Reference yield:

: 26116-12-1
1-ethyl-2-pyrrolidinemethanamine

: 90763-32-9
N-<(1-ethyl-2-pyrrolidinyl)methyl>-2-methoxy-4-chloro-5-<(methylsulfamoyl)amino>benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: Et₃N / CH₂Cl₂ / 0.25 h / Ambient temperature

2: 81 percent / Sn, HCl aq. / 4 h / 50 °C

3: 67 percent / Et₃N / CH₂Cl₂ / 0.25 h

With hydrogenchloride; tin; triethylamine; In dichloromethane;
DOI:10.1021/jm00375a009

Reference yield:

: 68255-77-6
2-methoxy-4-chloro-5-nitrobenzoic acid

: 90763-32-9
N-<(1-ethyl-2-pyrrolidinyl)methyl>-2-methoxy-4-chloro-5-<(methylsulfamoyl)amino>benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: SOCl₂ / 0.5 h / Heating

2: Et₃N / CH₂Cl₂ / 0.25 h / Ambient temperature

3: 81 percent / Sn, HCl aq. / 4 h / 50 °C

4: 67 percent / Et₃N / CH₂Cl₂ / 0.25 h

With hydrogenchloride; tin; thionyl chloride; triethylamine; In dichloromethane;
DOI:10.1021/jm00375a009