2-Acetamido-5-nitropyridine

Base Information

• Chemical Name: 2-Acetamido-5-nitropyridine
• CAS No.: 5093-64-1
• Molecular Formula: C7H7N3O3
• Molecular Weight: 181.151
• Hs Code.: 29333990
• Mol file: 5093-64-1.mol

Synonyms:Acetamide,N-(5-nitro-2-pyridyl)- (8CI);Pyridine, 2-acetamido-5-nitro- (6CI,7CI);2-Acetylamino-5-nitropyridine;N-(5-Nitropyridin-2-yl)acetamide;NSC 402463;

Chemical Property of 2-Acetamido-5-nitropyridine

Chemical Property:

• Vapor Pressure: 7.69E-08mmHg at 25°C
• Melting Point: 199-203 °C(lit.)
• Refractive Index: 1.625
• Boiling Point: 437.1 °C at 760 mmHg
• PKA: 12.61±0.70(Predicted)
• Flash Point: 218.1 °C
• PSA: 87.81000
• Density: 1.419 g/cm³
• LogP: 1.54440
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility.: soluble in Dimethylformamide

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Acetamido-5-nitropyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 37/38-41
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Acetamido-5-nitropyridine

There total 8 articles about 2-Acetamido-5-nitropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

5-nitro-pyridin-2-ylamine (4214-76-0,67476-67-9) → N-(5-aminopyridin-2-yl)acetamide (29958-14-3) + 2-acetamido-5-nitropyridine (5093-64-1)

Guidance literature:

With sulfuric acid; In acetic anhydride;

Reference yield: 86.0%

5-nitro-pyridin-2-ylamine (4214-76-0,67476-67-9) + acetic anhydride (108-24-7) → 2-acetamido-5-nitropyridine (5093-64-1)

Guidance literature:

With pyridine; dmap; at 0 - 20 ℃;

Reference yield: 80.1%

5-nitro-pyridin-2-ylamine (4214-76-0,67476-67-9) + acetyl chloride (75-36-5) → 2-acetamido-5-nitropyridine (5093-64-1)

Guidance literature:

With pyridine; In tetrahydrofuran; at 0 - 20 ℃; for 2h;

upstream raw materials:

5-nitro-pyridin-2-ylamine

acetic anhydride

acetyl chloride

dmap

Downstream raw materials:

N-(5-aminopyridin-2-yl)acetamide

C₇H₇N₃O₃*C₇H₈O₃S

Refernces

• 1、 Amangasieva,Borovlev,Demidov,Avakyan,Borovleva. "Synthesis of Amides by Nucleophilic Substitution of Hydrogen in 3-Nitropyridine". . p. 867 - 872. Retrieved 2018/07/31.
• 2、 Chikkulapalli, Anil,Aavula, Sanjeev Kumar,Mona Np, Rifahath,Karthikeyan, Karthikeyan,Kumar C.H., Vinodh,Sulur G., Manjunatha,Sumathi, Shanmugam. "Convenient N-acetylation of amines in N,N-dimethylacetamide with N,N-carbonyldiimidazole". supporting information. p. 3799 - 3803. Retrieved 2015/06/08.