5-methyloxolane-2,4-dione

Base Information

• Chemical Name: 5-methyloxolane-2,4-dione
• CAS No.: 5457-19-2
• Molecular Formula: C5H6 O3
• Molecular Weight: 114.101
• Hs Code.: 2932190090
• Mol file: 5457-19-2.mol

Synonyms:Valericacid, 4-hydroxy-3-oxo-, g-lactone (6CI); 5-Methyltetronic acid; NSC 21362

Chemical Property of 5-methyloxolane-2,4-dione

Chemical Property:

• Vapor Pressure: 0.00199mmHg at 25°C
• Melting Point: 115 °C
• Boiling Point: 291.1°Cat760mmHg
• PKA: 10.71±0.40(Predicted)
• Flash Point: 132.1°C
• PSA: 43.37000
• Density: 1.23g/cm³
• LogP: -0.10910

Purity/Quality:

99%min ^*data from raw suppliers

5-methyl-2,4(3H,5H)-Furandione 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-methyloxolane-2,4-dione

There total 11 articles about 5-methyloxolane-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-4-benzyloxy-5-methylfuran-2(5H)-one → (R)-4-hydroxy-5-methylfuran-2(5H)-one (22885-98-9) + (R)-5-methyltetronic acid (5457-19-2)

Guidance literature:

With 5%-palladium/activated carbon; hydrogen; In methanol; at 20 ℃; for 1.5h; under 750.075 Torr; Overall yield = 99 %; Overall yield = 1.12 g;

DOI:10.1055/s-0035-1562625

Reference yield:

(R)-2-(Acetoxy)propionsaeure-ethylester (20918-92-7) → (R)-5-methyltetronic acid (5457-19-2)

Guidance literature:

With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 1h;

DOI:10.1021/jacs.9b00110

Reference yield:

→ (R)-5-methyltetronic acid (5457-19-2)

Guidance literature:

With palladium on activated charcoal; water; Hydrogenation;

upstream raw materials:

(4R)-2-bromo-4-hydroxy-3-oxo-valeric acid-lactone

hydrogenchloride

(R)-2-(Acetoxy)propionsaeure-ethylester

(+/-)-2-bromo-4-hydroxy-3-oxo-valeric acid-lactone

Downstream raw materials:

2-(2-Benzyloxy-3,4-dimethoxy-phenyl)-3,4,7-trimethyl-7H-furo[3,4-b]pyridin-5-one

2-(2-Benzyloxy-3,4-dimethoxy-phenyl)-3,7-dimethyl-5-oxo-5,7-dihydro-furo[3,4-b]pyridine-4-carbaldehyde

4-Acetyl-6-(2-benzyloxy-3,4-dimethoxy-phenyl)-7-methyl-pyrrolo[3,4-c]pyridine-1,3-dione

2-(2-Benzyloxy-3,4-dimethoxy-phenyl)-3-methyl-7-methylene-5-oxo-5,7-dihydro-furo[3,4-b]pyridine-4-carboxylic acid methyl ester

Refernces

• 1、 Linder, David,Schobert, Rainer. "A Short Synthesis of the Mould Metabolite (R)-(+)-Carolinic Acid from (S)-Lactic Acid". . p. 4564 - 4568. Retrieved 2016/12/14.