Technology Process of 2-Propenoic acid,
3-[4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-methoxyphenyl]-,
(1,1-dimethylethyl)dimethylsilyl ester
There total 1 articles about 2-Propenoic acid,
3-[4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-methoxyphenyl]-,
(1,1-dimethylethyl)dimethylsilyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
N-ethyl-N,N-diisopropylamine;
In
dichloromethane;
at 20 ℃;
for 16h;
Inert atmosphere;
DOI:10.1002/anie.201408641
- Guidance literature:
-
With
sodium carbonate;
In
tetrahydrofuran; water;
at 25 - 30 ℃;
for 4h;
Reagent/catalyst;
Temperature;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: potassium carbonate; water / tetrahydrofuran / 1.5 h / 20 °C / Inert atmosphere
2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 2 h / 20 °C / Inert atmosphere
3.1: acetic acid; tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 0 °C / Inert atmosphere
4.1: hexane / 7 h / 20 °C / Inert atmosphere; Irradiation
5.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 °C / Inert atmosphere
6.1: [bis(acetoxy)iodo]benzene / 2,2,2-trifluoroethanol; acetone / 1 h / -40 °C / Inert atmosphere
6.2: Inert atmosphere
With
dmap; lithium aluminium tetrahydride; [bis(acetoxy)iodo]benzene; tetrabutyl ammonium fluoride; water; potassium carbonate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
In
tetrahydrofuran; hexane; dichloromethane; 2,2,2-trifluoroethanol; acetone;
DOI:10.1002/anie.201408641
