1-Piperidinecarboxylic acid, 4-[[[2,4-dichloro-3-[[(2,4-dimethyl-8-quinolinyl)oxy]methyl]phenyl]sulfonyl] amino]-4-(1-piperazinylcarbonyl)-, 1,1-dimethylethyl ester

Base Information

Chemical Name:1-Piperidinecarboxylic acid, 4-[[[2,4-dichloro-3-[[(2,4-dimethyl-8-quinolinyl)oxy]methyl]phenyl]sulfonyl] amino]-4-(1-piperazinylcarbonyl)-, 1,1-dimethylethyl ester
CAS No.:928851-54-1
Molecular Formula:C33H41Cl2N5O6S
Molecular Weight:706.69
Hs Code.:

1-Piperidinecarboxylic acid,
4-[[[2,4-dichloro-3-[[(2,4-dimethyl-8-quinolinyl)oxy]methyl]phenyl]sulfonyl]
amino]-4-(1-piperazinylcarbonyl)-, 1,1-dimethylethyl ester

Synonyms:

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Chemical Property of 1-Piperidinecarboxylic acid, 4-[[[2,4-dichloro-3-[[(2,4-dimethyl-8-quinolinyl)oxy]methyl]phenyl]sulfonyl] amino]-4-(1-piperazinylcarbonyl)-, 1,1-dimethylethyl ester

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Technology Process of 1-Piperidinecarboxylic acid, 4-[[[2,4-dichloro-3-[[(2,4-dimethyl-8-quinolinyl)oxy]methyl]phenyl]sulfonyl] amino]-4-(1-piperazinylcarbonyl)-, 1,1-dimethylethyl ester

There total 5 articles about 1-Piperidinecarboxylic acid, 4-[[[2,4-dichloro-3-[[(2,4-dimethyl-8-quinolinyl)oxy]methyl]phenyl]sulfonyl] amino]-4-(1-piperazinylcarbonyl)-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1026061-56-2
4-{1-tert-butoxycarbonyl-4-[2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-benzenesulfonylamino]-piperidine-4-carbonyl}-piperazine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester

: 928851-54-1
4-[2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-benzenesulfonylamino]-4-(piperazine-1-carbonyl)-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: With piperidine; In N,N-dimethyl-formamide; at 20 ℃; for 1h;
DOI:10.1021/jm061143k

Reference yield:

: 188440-21-3
3-bromomethyl-2,4-dichlorobenzenesulphonyl chloride

: 928851-54-1
4-[2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-benzenesulfonylamino]-4-(piperazine-1-carbonyl)-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: trimethylsilyl chloride; N,O-bis-trimethylsilylacetamide / tetrahydrofuran / 2 h / Heating

1.2: tetrahydrofuran

1.3: NaBr / acetone; dimethylformamide / 20 °C

2.1: LiOH / acetonitrile / 1.5 h / 20 °C

2.2: acetonitrile; dimethylformamide / 20 °C

3.1: N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide; 1-hydroxybenzotriazole; diisopropylethylamine / dimethylformamide

4.1: piperidine / dimethylformamide / 1 h / 20 °C

With piperidine; lithium hydroxide; chloro-trimethyl-silane; N,O-bis-(trimethylsilyl)-acetamide; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm061143k

Reference yield:

: 1026484-91-2
4-(3-bromomethyl)-2,4-dichloro-phenylsulfonamido-1-(tert-butoxycarbonyl)piperidine-4-carboxylic acid

: 928851-54-1
4-[2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-benzenesulfonylamino]-4-(piperazine-1-carbonyl)-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: LiOH / acetonitrile / 1.5 h / 20 °C

1.2: acetonitrile; dimethylformamide / 20 °C

2.1: N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide; 1-hydroxybenzotriazole; diisopropylethylamine / dimethylformamide

3.1: piperidine / dimethylformamide / 1 h / 20 °C

With piperidine; lithium hydroxide; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm061143k