4-(3-bromomethyl)-2,4-dichloro-phenylsulfonamido-1-(tert-butoxycarbonyl)piperidine-4-carboxylic acid

Base Information

• Chemical Name: 4-(3-bromomethyl)-2,4-dichloro-phenylsulfonamido-1-(tert-butoxycarbonyl)piperidine-4-carboxylic acid
• CAS No.: 1026484-91-2
• Molecular Formula: C₁₈H₂₃BrCl₂N₂O₆S
• Molecular Weight: 546.266
• Mol file: 1026484-91-2.mol

Synonyms:4-(3-bromomethyl)-2,4-dichloro-phenylsulfonamido-1-(tert-butoxycarbonyl)piperidine-4-carboxylic acid

Chemical Property of 4-(3-bromomethyl)-2,4-dichloro-phenylsulfonamido-1-(tert-butoxycarbonyl)piperidine-4-carboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(3-bromomethyl)-2,4-dichloro-phenylsulfonamido-1-(tert-butoxycarbonyl)piperidine-4-carboxylic acid

There total 2 articles about 4-(3-bromomethyl)-2,4-dichloro-phenylsulfonamido-1-(tert-butoxycarbonyl)piperidine-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-bromomethyl-2,4-dichlorobenzenesulphonyl chloride (188440-21-3) + 4-amino-1-(tert-butoxycarbonyl)piperidine-4-carboxylic acid (183673-71-4) → 4-(3-bromomethyl)-2,4-dichloro-phenylsulfonamido-1-(tert-butoxycarbonyl)piperidine-4-carboxylic acid (1026484-91-2)

Guidance literature:

4-amino-1-(tert-butoxycarbonyl)piperidine-4-carboxylic acid; With chloro-trimethyl-silane; N,O-bis-(trimethylsilyl)-acetamide; In tetrahydrofuran; for 2h; Heating;

3-bromomethyl-2,4-dichlorobenzenesulphonyl chloride; In tetrahydrofuran;

With sodium bromide; In N,N-dimethyl-formamide; acetone; at 20 ℃;

DOI:10.1021/jm061143k

Reference yield:

2,4-Dichloro-3-methylbenzenesulfonyl chloride (69145-58-0) → 4-(3-bromomethyl)-2,4-dichloro-phenylsulfonamido-1-(tert-butoxycarbonyl)piperidine-4-carboxylic acid (1026484-91-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: N-bromosuccinimide; AIBN / CCl₄

2.1: trimethylsilyl chloride; N,O-bis-trimethylsilylacetamide / tetrahydrofuran / 2 h / Heating

2.2: tetrahydrofuran

2.3: NaBr / acetone; dimethylformamide / 20 °C

With N-Bromosuccinimide; chloro-trimethyl-silane; N,O-bis-(trimethylsilyl)-acetamide; 2,2'-azobis(isobutyronitrile); In tetrahydrofuran; tetrachloromethane;

DOI:10.1021/jm061143k

Reference yield:

4-(3-bromomethyl)-2,4-dichloro-phenylsulfonamido-1-(tert-butoxycarbonyl)piperidine-4-carboxylic acid (1026484-91-2) + 8-hydroxy-2,4-dimethylquinoline (115310-98-0) → 4-[2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-benzenesulfonylamino]-piperidine-1,4-dicarboxylic acid mono-tert-butyl ester (928851-48-3)

Guidance literature:

8-hydroxy-2,4-dimethylquinoline; With lithium hydroxide; In acetonitrile; at 20 ℃; for 1.5h;

4-(3-bromomethyl)-2,4-dichloro-phenylsulfonamido-1-(tert-butoxycarbonyl)piperidine-4-carboxylic acid; In N,N-dimethyl-formamide; acetonitrile; at 20 ℃;

DOI:10.1021/jm061143k

upstream raw materials:

3-bromomethyl-2,4-dichlorobenzenesulphonyl chloride

4-amino-1-(tert-butoxycarbonyl)piperidine-4-carboxylic acid

2,4-Dichloro-3-methylbenzenesulfonyl chloride

Downstream raw materials:

4-[2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-benzenesulfonylamino]-piperidine-1,4-dicarboxylic acid mono-tert-butyl ester

4-[2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-benzenesulfonylamino]-1-methyl-piperidine-4-carboxylic acid

1-acetyl-4-[2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-benzenesulfonylamino]-piperidine-4-carboxylic acid

2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-N-[1-methyl-4-(piperazine-1-carbonyl)-piperidin-4-yl]-benzenesufonamide