Chemical Property of Perhexiline maleate
Chemical Property:
- Vapor Pressure:1.13E-14mmHg at 25°C
- Melting Point:181-183°C
- Boiling Point:574.1°C at 760 mmHg
- Flash Point:301°C
- PSA：86.63000
- LogP:5.33600
- Storage Temp.:-20?C Freezer, Under Inert Atmosphere
- Solubility.:DMSO: ≥5mg/mL
- Hydrogen Bond Donor Count:3
- Hydrogen Bond Acceptor Count:5
- Rotatable Bond Count:6
- Exact Mass:393.28790873
- Heavy Atom Count:28
- Complexity:364
- Purity/Quality:
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98%,99%, *data from raw suppliers
racPerhexilineMaleate *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:C1CCC(CC1)C(CC2CCCCN2)C3CCCCC3.C(=CC(=O)O)C(=O)O
- Isomeric SMILES:C1CCC(CC1)C(CC2CCCCN2)C3CCCCC3.C(=C\C(=O)O)\C(=O)O
- Recent EU Clinical Trials:Myocardial protection with Perhexiline in Left Ventricular Hypertrophy
- Recent NIPH Clinical Trials:Approved calcium channel blocker in the treatment of fibrodysplasia ossificans progressiva (FOP)
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Description
Perhexiline is a carnitine palmitoyltransferase 1 (CPT1) and CPT2 inhibitor that was originally developed as an anti-anginal drug in the 1970s. It inhibits rat heart and liver CPT1 (IC50 = 77 and 148 μM, respectively) and rat heart CPT2 (IC50 = 79 μM). Inhibition of CPT reduces uptake of long-chain fatty acids into the mitochondria, thereby shifting cellular metabolism from β-oxidation to glycolysis. Perhexilin inhibits mTORC1 signaling at 10 μM and induces autophagy ~7-fold at a concentration of 10 μM in MCF-7 cells.
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Uses
PERHEXILINE MALEATE SALT is a Vasodilator, used in treatments for angina. H1 antihistamine Perhexiline maleate salt has been used to block fatty acid oxidation. It has also been used as 5′?adenosine?monophosphate-activated?protein kinase?(AMPK)?activator and in worm lifespan assay.
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Therapeutic Function
Coronary vasodilator
