CAS No.6724-53-4,PERHEXILINE MALEATE SALT Suppliers

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Basic Information

Molecular Structure:
CAS No.:	6724-53-4
Name:	PERHEXILINE MALEATE SALT
Article Data:	2

Formula:	C₁₉H₃₅N•C₄H₄O₄
Molecular Weight:	393.567
Synonyms:	2-[2,2-DICYCLOHEXYLETHYL]PIPERIDINE MALEATE SALT;PERHEXILINE MALEATE SALT;2-(2,2-dicyclohexylethyl)piperidinemaleate;2-(2,2-dicyclohexylethyl)-piperidinmaleate(1:1);perhexilinemaleate;2-(2,2-dicyclohexylethyl)piperidinium hydrogen maleate;perhexilene maleate
Melting Point:	181-183°C
Boiling Point:	574.1°C at 760 mmHg
Flash Point:	301°C
Safety:	Poison by intraperitoneal route. Moderately toxic by ingestion. Human systemic effects by ingestion: muscle weakness, paresthesia, and hepatitis. Mutation data reported. When heated to decomposition it emits toxic fumes of NO_x.
PSA:	86.63000
LogP:	5.33600

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Chemistry

IUPAC Name: (Z)-But-2-enedioic acid ; 2-(2,2-Dicyclohexylethyl)piperidine
Synonyms: 1,1-Dicyclohexyl-2-(2-piperidyl)ethane Maleate ; 2-(2,2-Dicyclohexylethyl)piperidine (2Z)-2-butenedioate (1:1) ; 2-(2,2-Dicyclohexylethyl)piperidine (2Z)-but-2-enedioate (1:1) ; Piperidine, 2-(2,2-dicyclohexylethyl)-, (2Z)-2-butenedioate (1:1)
CAS NO: 6724-53-4
Molecular Formula of Perhexiline maleate (CAS NO.6724-53-4) : C₂₃H₃₉NO₄
Molecular Weight of Perhexiline maleate (CAS NO.6724-53-4) : 393.56
Molecular Structure of Perhexiline maleate (CAS NO.6724-53-4) :
EINECS: 229-775-5
Flash Point: 164.5 °C
Enthalpy of Vaporization: 58.35 kJ/mol
Boiling Point: 340 °C at 760 mmHg
Vapour Pressure: 8.88E-05 mmHg at 25°C

Uses

Perhexiline maleate (CAS NO.6724-53-4) is used for angina and arrhythmia.

Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
man	LDLo	oral	4693mg/kg/3Y (4693mg/kg)	BEHAVIORAL: MUSCLE WEAKNESS LIVER: "HEPATITIS, FIBROUS (CIRRHOSIS, POST-NECROTIC SCARRING)"	New Zealand Medical Journal. Vol. 96, Pg. 202, 1983.
man	TDLo	oral	636mg/kg/89D- (636mg/kg)	LIVER: "JAUNDICE, OTHER OR UNCLASSIFIED" SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"	British Journal of Clinical Practice. Vol. 31, Pg. 136, 1977.
mouse	LD50	intraperitoneal	107mg/kg (107mg/kg)	BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Oyo Yakuri. Pharmacometrics. Vol. 21, Pg. 83, 1981.
mouse	LD50	oral	2641mg/kg (2641mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA	Oyo Yakuri. Pharmacometrics. Vol. 14, Pg. 337, 1977.
mouse	LD50	subcutaneous	> 2gm/kg (2000mg/kg)	SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" SKIN AND APPENDAGES (SKIN): HAIR: OTHER	Oyo Yakuri. Pharmacometrics. Vol. 21, Pg. 83, 1981.
rat	LD50	intraperitoneal	106mg/kg (106mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Oyo Yakuri. Pharmacometrics. Vol. 21, Pg. 83, 1981.
rat	LD50	oral	2150mg/kg (2150mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA	Oyo Yakuri. Pharmacometrics. Vol. 14, Pg. 337, 1977.
rat	LD50	subcutaneous	> 2gm/kg (2000mg/kg)	SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" SKIN AND APPENDAGES (SKIN): HAIR: OTHER	Oyo Yakuri. Pharmacometrics. Vol. 21, Pg. 83, 1981.

Safety Profile

Poison by intraperitoneal route. Moderately toxic by ingestion. Human systemic effects by ingestion: muscle weakness, paresthesia, and hepatitis. Mutation data reported. When heated to decomposition it emits toxic fumes of NO_x.
WGK Germany 2
RTECS TM7068000