2-Methyl-3-(2-methylphenyl)pyrido[2,3-d]pyrimidin-4-one

Base Information

• Chemical Name: 2-Methyl-3-(2-methylphenyl)pyrido[2,3-d]pyrimidin-4-one
• CAS No.: 14133-24-5
• Molecular Formula: C15H13 N3 O
• Molecular Weight: 251.288
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID30161693
• Wikidata: Q83030145
• ChEMBL ID: CHEMBL30397
• Mol file: 14133-24-5.mol

Synonyms:2-methyl-3-(2'-methylphenyl)-4-oxo-3,4-dihydropyrido(2,3-d)pyrimidine;Kr 100;Kr-100

Chemical Property of 2-Methyl-3-(2-methylphenyl)pyrido[2,3-d]pyrimidin-4-one

Chemical Property:

• Vapor Pressure: 1.39E-07mmHg at 25°C
• Boiling Point: 429.5°Cat760mmHg
• Flash Point: 213.6°C
• PSA: 47.78000
• Density: 1.22g/cm³
• LogP: 2.39750
• XLogP3: 2.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 251.105862047
• Heavy Atom Count: 19
• Complexity: 393

Purity/Quality:

KR 100 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=CC=C1N2C(=NC3=C(C2=O)C=CC=N3)C

Technology Process of 2-Methyl-3-(2-methylphenyl)pyrido[2,3-d]pyrimidin-4-one

There total 12 articles about 2-Methyl-3-(2-methylphenyl)pyrido[2,3-d]pyrimidin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

2-Methyl-4H-pyrido<2,3-d><3,1>oxazin-4-one (3809-93-6) + o-toluidine (95-53-4) → 2-methyl-3-(2-methylphenyl)pyrido<2,3-d>pyrimidin-4(3H)-one (14133-24-5)

Guidance literature:

In toluene; for 8h; Heating;

DOI:10.1016/j.bmc.2004.07.068

Reference yield: 31.0%

o-toluidine hydrochloride (636-21-5,22006-17-3) + 2-Acetamido-3-pyridincarbonsaeure-ethylester (82417-91-2) → 2-methyl-3-(2-methylphenyl)pyrido<2,3-d>pyrimidin-4(3H)-one (14133-24-5)

Guidance literature:

With N,N-dimethyl-cyclohexanamine; phosphorus pentoxide; at 200 ℃; for 0.166667h;

Reference yield: 31.0%

2-acetamidonicotinic acid (17782-03-5) + o-toluidine (95-53-4) → 2-methyl-3-(2-methylphenyl)pyrido<2,3-d>pyrimidin-4(3H)-one (14133-24-5)

Guidance literature:

at 180 ℃; for 0.25h;

DOI:10.1007/BF00799933

upstream raw materials:

2-acetylamino-nicotinic acid methyl ester

o-toluidine

o-toluidine hydrochloride

2-Acetamido-3-pyridincarbonsaeure-ethylester

Downstream raw materials:

2-(3,4-methylenedioxystyryl)-3-(2-methylphenyl)pyrido<2,3-d>pyrimidin-4(3H)-one

10-aza-5,6-dihydro-2-ethyl-3-hydroxy-5-(2-methylphenyl)-1H-pyrido<1,2-a>quinazoline-1,6-dione

10-aza-5,6-dihydro-3-hydroxy-2-isopropyl-5-(2-methylphenyl)-1H-pyrido<1,2-a>quinazoline-1,6-dione

10-aza-5,6-dihydro-3-hydroxy-5-(2-methylphenyl)-2-phenyl-1H-pyrido<1,2-a>quinazoline-1,6-dione

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