17782-03-5

Basic information

• Product Name: 2-Acetamidonicotinic acid
• Synonyms: 2-Acetamidonicotinic acid;3-Pyridinecarboxylic acid, 2-(acetylamino)-
• CAS NO: 17782-03-5
• Molecular Formula: C₈H₈N₂O₃
• Molecular Weight: 180.16
• Product Categories: pharmacetical
• Mol File: 17782-03-5.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 465.2°Cat760mmHg
• Flash Point: 235.1°C
• Appearance: /
• Density: 1.404g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.628
• CAS DataBase Reference: 2-Acetamidonicotinic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Acetamidonicotinic acid(17782-03-5)
• EPA Substance Registry System: 2-Acetamidonicotinic acid(17782-03-5)

Safety Data

• Statements: 20/21/22
• Safety Statements: 24/25-36/37
• Hazardous Substances Data: 17782-03-5(Hazardous Substances Data)

Usage

Chemical Properties

White to light yellow solid

InChI:InChI=1/C8H8N2O3/c1-5(11)10-7-6(8(12)13)3-2-4-9-7/h2-4H,1H3,(H,12,13)(H,9,10,11)

Upstream product

• 5345-47-1 2-aminopyridin-3-carboxylic acid 
• 108-24-7 acetic anhydride 
• 2942-59-8 2-chloronicotinic acid 
• 2398-81-4 Nicotinic acid N-oxide 
• 59-67-6 nicotinic acid 
• 3809-93-6 2-Methyl-4H-pyrido<2,3-d><3,1>oxazin-4-one 

Downstream Products

• 76285-12-6 2-Styryl-3-(2',4'-dimethylphenyl)-4-oxo-3,4-dihydropyrido<2,3-d>pyrimidin 
• 90136-77-9 10-aza-5,6-dihydro-3-hydroxy-5-(2-methylphenyl)-2-phenyl-1H-pyrido<1,2-a>quinazoline-1,6-dione 
• 90136-78-0 10-aza-5,6-dihydro-3-hydroxy-2-isopropyl-5-(2-methylphenyl)-1H-pyrido<1,2-a>quinazoline-1,6-dione 
• 90136-76-8 10-aza-5,6-dihydro-2-ethyl-3-hydroxy-5-(2-methylphenyl)-1H-pyrido<1,2-a>quinazoline-1,6-dione 
• 90136-74-6 2-(3,4-methylenedioxystyryl)-3-(2-methylphenyl)pyrido<2,3-d>pyrimidin-4(3H)-one 
• 90136-75-7 2-(4-hydroxy-3-methoxystyryl)-3-(2-methylphenyl)pyrido<2,3-d>pyrimidin-4(3H)-one 
• 76285-19-3 3-(2-methylphenyl)-2-styryl-pyrido<2,3-d>pyrimidin-4(3H)-one 
• 14196-99-7 3-(4-bromophenyl)-2-methyl-pyrido<2,3-d>pyrimidin-4(3H)-one 
• 76285-20-6 3-Benzyl-2-methyl-3H-pyrido[2,3-d]pyrimidin-4-one 
• 14133-24-5 2-methyl-3-(2-methylphenyl)pyrido<2,3-d>pyrimidin-4(3H)-one 
• 15511-44-1 2-Methyl-3-(2',4'-dimethylphenyl)-4-oxo-3,4-dihydropyrido<2,3-d>pyrimidin 
• 76285-13-7 3-(2-chlorophenyl)-2-methyl-pyrido<2,3-d>pyrimidin-4(3H)-one 
• 76285-14-8 3-(3-chloro-phenyl)-2-methyl-3H-pyrido[2,3-d]pyrimidin-4-one 
• 76285-18-2 2-Methyl-3-phenethyl-3H-pyrido[2,3-d]pyrimidin-4-one 

Relevant articles and documents

On derivatives of 4-oxo-3,4-dihydropyrido[2,3-d]pyrimidine (author's transl)

A typical representative of the hypnotic and anticonvulsive 4-quinazoline group is methaqualone (1). A number of new derivatives of 4-oxo-3,4-dihydropyrido[2,3-d]pyrimidine (10) were synthetized by substituting the benzene ring in the quinazolone molecule by the pyridine ring. The synthesis was achieved by the condensation of 2-acetaminonicotinic acid (9) and a primary amine or by the reaction of 2-aminonicotinic acid (8) with acetic acid and a primary amine. These new compounds were tested on animals for antiphlogistic, analgetic and antipyretic activities and for effects on the central nervous system as well. It was tried to establish, on the basis of the results obtained, relations between the chemical constitution and the pharmacological efficacy. It was found that, depending on the nature of the substituents in the position 3; either the antiphlogistic, analgetic and antipyretic effects or the anticonvulsive action will prevail.