4-Bromo-1-benzothiophene-2-carbonyl chloride

Base Information

• Chemical Name: 4-Bromo-1-benzothiophene-2-carbonyl chloride
• CAS No.: 93104-01-9
• Molecular Formula: C₉H₄BrClOS
• Molecular Weight: 275.553
• Hs Code.: 2934999090
• Mol file: 93104-01-9.mol

Synonyms:4-Bromobenzo[b]thiophene-2-carbonyl chloride;4-bromo-2-chloroformylbenzo[b]thiophene;4-Bromo-2-(chlorocarbonyl)-1-benzothiophene;

Chemical Property of 4-Bromo-1-benzothiophene-2-carbonyl chloride

Chemical Property:

• PSA: 45.31000
• LogP: 4.04280

Purity/Quality:

98%min ^*data from raw suppliers

4-Bromo-1-benzothiophene-2-carbonyl chloride 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Bromo-1-benzothiophene-2-carbonyl chloride

There total 4 articles about 4-Bromo-1-benzothiophene-2-carbonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-bromo-benzo[b]thiophene-2-carboxylic acid (5194-37-6) → 4-bromo-2-chloroformylbenzothiophene (93104-01-9)

Guidance literature:

With thionyl chloride; In benzene; Heating;

Reference yield:

ethyl 5-amino-1-benzothiophene-2-carboxylate (25785-10-8) → 4-bromo-2-chloroformylbenzothiophene (93104-01-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 91 percent / bromine, anhydreous sodium acetate / acetic acid / roomtemp., 1 h, then 15 min heating

3: 95 percent / 50percent sulphuric acid / acetic acid / reflux, 8h, then room temp.

4: thionylchloride / benzene / Heating

With thionyl chloride; sulfuric acid; bromine; sodium acetate; In acetic acid; benzene;

Reference yield:

4-bromobenzo[b]thiophene-2-carboxylic acid ethyl ester (93103-82-3) → 4-bromo-2-chloroformylbenzothiophene (93104-01-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / 50percent sulphuric acid / acetic acid / reflux, 8h, then room temp.

2: thionylchloride / benzene / Heating

With thionyl chloride; sulfuric acid; In acetic acid; benzene;

upstream raw materials:

4-bromo-benzo[b]thiophene-2-carboxylic acid

ethyl 5-amino-1-benzothiophene-2-carboxylate

4-bromobenzo[b]thiophene-2-carboxylic acid ethyl ester

5-amino-4-bromo-2-carbethoxybenzothiophene

Refernces