4-FLUORO-3-METHYLACETOPHENONE

Base Information

• Chemical Name: 4-FLUORO-3-METHYLACETOPHENONE
• CAS No.: 369-32-4
• Molecular Formula: C9H9FO
• Molecular Weight: 152.168
• Hs Code.: 2914700090
• Mol file: 369-32-4.mol

Synonyms:Acetophenone,4'-fluoro-3'-methyl- (8CI);1-(4-Fluoro-3-methylphenyl)ethanone;3'-Methyl-4'-fluoroacetophenone;NSC 151042;

Chemical Property of 4-FLUORO-3-METHYLACETOPHENONE

Chemical Property:

• Appearance/Colour: colourless liquid
• Vapor Pressure: 0.093mmHg at 25°C
• Refractive Index: 1.493
• Boiling Point: 224 °C at 760 mmHg
• Flash Point: 86.5 °C
• PSA: 17.07000
• Density: 1.075 g/cm³
• LogP: 2.33670
• Storage Temp.: Sealed in dry,Room Temperature
• Water Solubility.: Insoluble in water.

Purity/Quality:

99%, ^*data from raw suppliers

4-Fluoro-3-methylacetophenone ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4'-Fluoro-3'-methylacetophenone is used as pharmaceutical intermediate, and an intermediate in organic synthesis.

Technology Process of 4-FLUORO-3-METHYLACETOPHENONE

There total 7 articles about 4-FLUORO-3-METHYLACETOPHENONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

→ 1-(4-fluoro-3-methylphenyl)ethanone (369-32-4)

Guidance literature:

Reference yield: 92.0%

1-(2-chloro-4-fluoro-5-methylphenyl)ethan-1-one (181827-49-6) → 1-(4-fluoro-3-methylphenyl)ethanone (369-32-4)

Guidance literature:

With potassium hydroxide; hydrogen; Aliquat 336; palladium on activated charcoal; In 2,2,4-trimethylpentane; at 50 ℃; for 1.5h; under 760 Torr;

DOI:10.1055/s-1996-4344

Reference yield: 91.0%

2-Fluorotoluene (95-52-3) + acetyl chloride (75-36-5) → 1-(4-fluoro-3-methylphenyl)ethanone (369-32-4)

Guidance literature:

With aluminum (III) chloride; In chloroform; at -5 - 20 ℃; for 2h; Solvent; Reagent/catalyst; Temperature;

upstream raw materials:

2-Fluorotoluene

acetyl chloride

1-(2-chloro-4-fluoro-5-methylphenyl)ethan-1-one

4-chloro-2-fluorotoluene

Downstream raw materials:

[4-(4-fluoro-3-methyl-phenyl)-thiazol-2-yl]-(4-fluoro-phenyl)-amine

4-(4-fluoro-3-methyl-phenyl)-thiazol-2-ylamine

5-Fluoro-3-[2-(4-fluoro-3-methyl-phenyl)-2-oxo-ethyl]-3-hydroxy-1,3-dihydro-indol-2-one

(E)-3-(2-Chloro-phenyl)-1-(4-fluoro-3-methyl-phenyl)-propenone

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