3'-Guanylic acid, 2'-deoxy-N-(2-methyl-1-oxopropyl)-6-O-[2-(4-nitrophenyl)ethyl]-, 2-chlorophenyl 2-cyanoethyl ester

Base Information

• Chemical Name: 3'-Guanylic acid, 2'-deoxy-N-(2-methyl-1-oxopropyl)-6-O-[2-(4-nitrophenyl)ethyl]-, 2-chlorophenyl 2-cyanoethyl ester
• CAS No.: 93130-38-2
• Molecular Formula: C31H33ClN7O10P
• Molecular Weight: 730.071
• Mol file: 93130-38-2.mol

Synonyms:

Chemical Property of 3'-Guanylic acid, 2'-deoxy-N-(2-methyl-1-oxopropyl)-6-O-[2-(4-nitrophenyl)ethyl]-, 2-chlorophenyl 2-cyanoethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3'-Guanylic acid, 2'-deoxy-N-(2-methyl-1-oxopropyl)-6-O-[2-(4-nitrophenyl)ethyl]-, 2-chlorophenyl 2-cyanoethyl ester

There total 1 articles about 3'-Guanylic acid, 2'-deoxy-N-(2-methyl-1-oxopropyl)-6-O-[2-(4-nitrophenyl)ethyl]-, 2-chlorophenyl 2-cyanoethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

5'-O-dimethoxytrityl-N2-isobutyryl-O6-<2-(p-nitrophenyl)ethyl>-2'-deoxyguanosine 3'-(2-chlorophenyl,2-cyanoethyl)phosphate (93183-95-0) → N2-isobutyryl-O6-<2-(p-nitrophenyl)ethyl>-2'-deoxyguanosine 3'-(2-chlorophenyl,2-cyanoethyl)phosphate (93130-38-2)

Guidance literature:

With dichloro-acetic acid; In dichloromethane; at 20 ℃; for 0.25h;

DOI:10.1002/hlca.19840670521

Reference yield:

5'-O-dimethoxytrityl-N2-isobutyryl-O6-<2-(p-nitrophenyl)ethyl>-2'-deoxyguanosine 3'-(2-chlorophenyl,triethylammonium)phosphate + N2-isobutyryl-O6-<2-(p-nitrophenyl)ethyl>-2'-deoxyguanosine 3'-(2-chlorophenyl,2-cyanoethyl)phosphate (93130-38-2) → C80H79Cl2N13O21P2

Guidance literature:

With 1-(mesitylene-2-sulfonyl)-3-nitro-1H-1,2,4-triazole; In pyridine; at 20 ℃; for 0.5h;

DOI:10.1002/hlca.19840670521

Reference yield:

bis(benzotriazol-1-yl)(2-chlorophenyl)phosphate (80817-46-5) + 5'-O-dimethoxytrityl-N2-isobutyryl-O6-<2-(p-nitrophenyl)ethyl>-2'-deoxyguanosine (90678-72-1) + N2-isobutyryl-O6-<2-(p-nitrophenyl)ethyl>-2'-deoxyguanosine 3'-(2-chlorophenyl,2-cyanoethyl)phosphate (93130-38-2) → C80H79Cl2N13O21P2

Guidance literature:

With 1-methyl-1H-imidazole; Multistep reaction; 1.) THF, pyridine, 20 deg C, 20 min; 2.) THF, pyridine, 20 deg C, 2 h;

DOI:10.1002/hlca.19840670521

upstream raw materials:

5'-O-dimethoxytrityl-N²-isobutyryl-O⁶-<2-(p-nitrophenyl)ethyl>-2'-deoxyguanosine 3'-(2-chlorophenyl,2-cyanoethyl)phosphate