Benzoic acid, 4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)-, ethyl ester, monohydrochloride

Base Information

Chemical Name:Benzoic acid, 4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)-, ethyl ester, monohydrochloride
CAS No.:93178-72-4
Molecular Formula:C16H18N2O2.ClH
Molecular Weight:306.792
Hs Code.:

Synonyms:

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Chemical Property of Benzoic acid, 4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)-, ethyl ester, monohydrochloride

Chemical Property:

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Technology Process of Benzoic acid, 4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)-, ethyl ester, monohydrochloride

There total 6 articles about Benzoic acid, 4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)-, ethyl ester, monohydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 93178-58-6
5-(p-ethoxycarbonylphenyl)-imidazo[1,5-a]pyridine

: 93178-72-4
5-<4-(ethoxycarbonyl)phenyl>-5,6,7,8-tetrahydroimidazo<1,5-a>pyridine hydrochloride

Guidance literature:: With hydrogenchloride; hydrogen; palladium on activated charcoal; In ethanol; at 60 ℃; for 4h; under 2068.6 Torr;
DOI:10.1021/jm00106a038

Reference yield:

: 4385-61-9
ethyl 4-(2-pyridinyl)benzoate

: 93178-72-4
5-<4-(ethoxycarbonyl)phenyl>-5,6,7,8-tetrahydroimidazo<1,5-a>pyridine hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1: 40percent peracetic acid / 3 h / 90 °C

2: 1.) dimethyl sulfate / 1.) toluene, 90 deg C, 3 h, 2.) water, 0 deg C, 24 h

3: 65 percent / H₂, conc. HCl / 10percent Pd/C / methanol / 760 Torr

4: 83 percent / 15 h / 90 °C

5: 73 percent / POCl₃ / toluene / 15 h / 90 °C

6: 85 percent / H₂, conc. HCl / 10percent Pd/C / ethanol / 4 h / 60 °C / 2068.6 Torr

With hydrogenchloride; peracetic acid; hydrogen; dimethyl sulfate; trichlorophosphate; palladium on activated charcoal; In methanol; ethanol; toluene;
DOI:10.1021/jm00106a038

Reference yield:

: 102676-38-0
2-<4-(ethoxycarbonyl)phenyl>pyridine N-oxide

: 93178-72-4
5-<4-(ethoxycarbonyl)phenyl>-5,6,7,8-tetrahydroimidazo<1,5-a>pyridine hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) dimethyl sulfate / 1.) toluene, 90 deg C, 3 h, 2.) water, 0 deg C, 24 h

2: 65 percent / H₂, conc. HCl / 10percent Pd/C / methanol / 760 Torr

3: 83 percent / 15 h / 90 °C

4: 73 percent / POCl₃ / toluene / 15 h / 90 °C

5: 85 percent / H₂, conc. HCl / 10percent Pd/C / ethanol / 4 h / 60 °C / 2068.6 Torr

With hydrogenchloride; hydrogen; dimethyl sulfate; trichlorophosphate; palladium on activated charcoal; In methanol; ethanol; toluene;
DOI:10.1021/jm00106a038