2-Propenoic acid, 3-(2-hydroxy-3-methoxyphenyl)-, methyl ester, (2E)-

Base Information

• Chemical Name: 2-Propenoic acid, 3-(2-hydroxy-3-methoxyphenyl)-, methyl ester, (2E)-
• CAS No.: 93198-69-7
• Molecular Formula: C11H12O4
• Molecular Weight: 208.214
• Mol file: 93198-69-7.mol

Synonyms:2-hydroxy-3-methoxy-trans-cinnamic acid methyl ester;2-Hydroxy-3-methoxy-trans-zimtsaeure-methylester;

Chemical Property of 2-Propenoic acid, 3-(2-hydroxy-3-methoxyphenyl)-, methyl ester, (2E)-

Chemical Property:

• Melting Point: 107-108 °C(Solv: ethyl acetate (141-78-6); ligroine (8032-32-4))
• Boiling Point: 339.6±27.0 °C(Predicted)
• PSA: 55.76000
• Density: 1.204±0.06 g/cm3(Predicted)
• LogP: 1.58700

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Propenoic acid, 3-(2-hydroxy-3-methoxyphenyl)-, methyl ester, (2E)-

There total 5 articles about 2-Propenoic acid, 3-(2-hydroxy-3-methoxyphenyl)-, methyl ester, (2E)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

3-methoxy-2-hydroxybenzaldehyde (148-53-8) + methyl (triphenylphosphoranylidene)acetate (21204-67-1,2605-67-6) → 8-methoxycoumarine (2445-81-0) + methyl (E)-β-(2-hydroxy-3-methoxyphenyl)acrylate (93198-69-7)

Guidance literature:

In toluene; for 30h; Heating;

DOI:10.1080/10426509808045482

Reference yield: 87.0%

methyl 3-(3-methoxy-2-(pyridin-2-ylsulfonyloxy)phenyl)acrylate → methyl (E)-β-(2-hydroxy-3-methoxyphenyl)acrylate (93198-69-7)

Guidance literature:

With water; ammonium chloride; zinc; In tetrahydrofuran; at 20 ℃;

DOI:10.1002/asia.201601413

Reference yield: 85.0%

3-methoxy-2-hydroxybenzaldehyde (148-53-8) + methyl (triphenylphosphoranylidene)acetate (21204-67-1,2605-67-6) → methyl (E)-β-(2-hydroxy-3-methoxyphenyl)acrylate (93198-69-7)

Guidance literature:

In dichloromethane; at 0 - 20 ℃; for 15h; Inert atmosphere;

DOI:10.3762/bjoc.8.186

upstream raw materials:

methanol

2-hydroxy-3-methoxy-trans-cinnamic acid

3-methoxy-2-hydroxybenzaldehyde

methyl (triphenylphosphoranylidene)acetate

Downstream raw materials:

(7-Methoxy-2,3-dihydro-benzofuran-3-yl)-acetic acid methyl ester

2-(2,3-dihydro-7-methoxybenzofuran-3-yl)acetic acid