Technology Process of Imidazo[1,2-a]pyrazine, 2-[2-methoxy-4-(methylsulfonyl)phenyl]-
There total 6 articles about Imidazo[1,2-a]pyrazine, 2-[2-methoxy-4-(methylsulfonyl)phenyl]- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogen; triethylamine;
Pd-BaSO4;
In
N,N-dimethyl-formamide;
for 0.025h;
under 3102.9 Torr;
Ambient temperature;
DOI:10.1021/jm00403a018
- Guidance literature:
-
Multi-step reaction with 7 steps
1: pyridine / CH2Cl2 / 1 h / 0 °C
2: 75 percent / aluminium chloride / 160 - 180 °C
3: 92 percent / sodium hydride / dimethylformamide / 1 h / 0 °C
4: 55 percent / potassium hydroxide / dimethylformamide / 2 h / 0 °C
5: 79 percent / m-chloroperbenzoic acid / CH2Cl2 / 1 h
6: 30 percent / dimethylformamide / 60 h / 40 °C
7: 20 percent / hydrogen, triethylamine / 5percent Pd/BaSO4 / dimethylformamide / 0.03 h / 3102.9 Torr / Ambient temperature
With
pyridine; potassium hydroxide; aluminium trichloride; hydrogen; sodium hydride; triethylamine; 3-chloro-benzenecarboperoxoic acid;
Pd-BaSO4;
In
dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00403a018
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 92 percent / sodium hydride / dimethylformamide / 1 h / 0 °C
2: 55 percent / potassium hydroxide / dimethylformamide / 2 h / 0 °C
3: 79 percent / m-chloroperbenzoic acid / CH2Cl2 / 1 h
4: 30 percent / dimethylformamide / 60 h / 40 °C
5: 20 percent / hydrogen, triethylamine / 5percent Pd/BaSO4 / dimethylformamide / 0.03 h / 3102.9 Torr / Ambient temperature
With
potassium hydroxide; hydrogen; sodium hydride; triethylamine; 3-chloro-benzenecarboperoxoic acid;
Pd-BaSO4;
In
dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00403a018
