N-Hydroxy-N-methylacetamide

Base Information

• Chemical Name: N-Hydroxy-N-methylacetamide
• CAS No.: 13115-24-7
• Molecular Formula: C3H7 N O2
• Molecular Weight: 89.0941
• Hs Code.: 2924199090
• NSC Number: 329234
• UNII: 7BXE337G7T
• DSSTox Substance ID: DTXSID10902425
• Nikkaji Number: J74.810B
• ChEMBL ID: CHEMBL4761573
• Mol file: 13115-24-7.mol

Synonyms:N-methyl acetohydroxamic acid;NMAH acid

Chemical Property of N-Hydroxy-N-methylacetamide

Chemical Property:

• Vapor Pressure: 2mmHg at 25°C
• Boiling Point: 144.7°C at 760 mmHg
• Flash Point: 41.3°C
• PSA: 40.54000
• Density: 1.114g/cm³
• LogP: -0.14610
• XLogP3: -0.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 89.047678466
• Heavy Atom Count: 6
• Complexity: 61.8

Purity/Quality:

N-HYDROXY-N-METHYLACETAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)N(C)O

Technology Process of N-Hydroxy-N-methylacetamide

There total 5 articles about N-Hydroxy-N-methylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

O-benzyl-N-methyl acetohydroxamic acid → N-methylacetohydroxamic acid (13115-24-7)

Guidance literature:

With 5%-palladium/activated carbon; hydrogen; In methanol; for 6h; under 750.075 Torr; Inert atmosphere;

DOI:10.1016/j.jinorgbio.2015.06.002

Reference yield: 83.0%

N,O-diacetyl-N-methylhydroxylamine (10328-61-7) → N-methylacetohydroxamic acid (13115-24-7)

Guidance literature:

With methanol; dmap; sodium methylate; at 60 ℃; for 4h; Inert atmosphere;

DOI:10.1021/ja205174c

Reference yield: 82.8%

N-methylhydroxyamine hydrochloride (4229-44-1) + acetyl chloride (75-36-5) → N-methylacetohydroxamic acid (13115-24-7)

Guidance literature:

With potassium carbonate; In tetrahydrofuran; Ambient temperature;

DOI:10.1055/s-1994-25645

upstream raw materials:

N,O-diacetyl-N-methylhydroxylamine

N-methylhydroxyamine hydrochloride

acetyl chloride

N-Methylhydroxylamine

Downstream raw materials:

O--N-methyl-N-acetyl-hydroxylamin

2-(N-acetyl-N-methylamino)-5-methylphenol

N-methyl-acetamide

N-methyl-N-phenoxyacetamide