Alphameprodine

Base Information

• Chemical Name: Alphameprodine
• CAS No.: 468-51-9
• Molecular Formula: C₁₇H₂₅NO₂
• Molecular Weight: 275.391
• Hs Code.: 2933399071
• European Community (EC) Number: 207-409-5
• UNII: 1177I648L1
• DSSTox Substance ID: DTXSID30196940
• Nikkaji Number: J239.347F
• Wikipedia: Meprodine
• Wikidata: Q16081287
• NCI Thesaurus Code: C76084
• Metabolomics Workbench ID: 146153
• ChEMBL ID: CHEMBL2104027
• Mol file: 468-51-9.mol

Synonyms:ALPHAMEPRODINE;Meprodine;468-51-9;Alfameprodina;Alphameprodinum;Alfameprodina [INN-Spanish];Alphameprodinum [INN-Latin];ACSCN-9608;IDS-NA-009;Alphameprodine [INN:BAN:DCF];UNII-1177I648L1;EINECS 207-409-5;3alpha-Ethyl-1-methyl-4-phenyl-4alpha-piperidyl propionat;alpha-3-Ethyl-1-methyl-4-phenyl-4-propionyloxypiperidine;1177I648L1;cis-3-Ethyl-1-methyl-4-phenyl-4-propionyloxypiperidine;(3S,4R)-3-Ethyl-1-methyl-4-phenylpiperidin-4-yl propanoate;DEA No. 9604;ALPHAMEPRODINE [INN];SCHEMBL907964;Alphameprodine [BAN:DCF:INN];CHEMBL2104027;DTXSID30196940;[(3S,4R)-3-ethyl-1-methyl-4-phenylpiperidin-4-yl] propanoate;AKOS015841984;DB01499;Q16081287;alpha-3-ethyl-1-methyl-4-phenyl-4-propionoxypiperidine;.ALPHA.-3-ETHYL-1-METHYL-4-PHENYL-4-PROPIONOXYPIPERIDINE;Propionic acid (4R)-3alpha-ethyl-1-methyl-4-phenylpiperidin-4-yl ester;4-PIPERIDINOL, 3-ETHYL-1-METHYL-4-PHENYL-, 4-PROPANOATE, (3R,4S)-REL-

 This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.

Chemical Property of Alphameprodine

Chemical Property:

• Vapor Pressure: 3.38E-05mmHg at 25°C
• Boiling Point: 354.3°Cat760mmHg
• PKA: 7.32±0.10(Predicted)
• Flash Point: 112.1°C
• PSA: 29.54000
• Density: 1.04g/cm³
• LogP: 3.13470
• XLogP3: 3.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• Exact Mass: 275.188529040
• Heavy Atom Count: 20
• Complexity: 325

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCC1CN(CCC1(C2=CC=CC=C2)OC(=O)CC)C
• Isomeric SMILES: CC[C@H]1CN(CC[C@@]1(C2=CC=CC=C2)OC(=O)CC)C

Technology Process of Alphameprodine

There total 3 articles about Alphameprodine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

propionic acid anhydride (123-62-6) → (+/-)-[3r-ethyl-1-methyl-4c-phenyl-4t-propionyloxy-piperidine (468-50-8,468-51-9,51372-89-5)

Guidance literature:

Edukt 1. eingesetzt im Gemisch mit dem Stereoisomeren; s. Verbindung /2004851800004/;

DOI:10.1021/jo01362a053

Reference yield:

phenyllithium (591-51-5) → (+/-)-[3r-ethyl-1-methyl-4t-phenyl-4c-propionyloxy-piperidine (468-50-8,468-51-9,51372-89-5)

Guidance literature:

Multi-step reaction with 2 steps

1: diethyl ether

With diethyl ether;

DOI:10.1021/jo01362a053

Reference yield:

(+/-)-3c-ethyl-1-methyl-4-phenyl-piperidin-4r-ol (51596-41-9,51704-07-5,51704-08-6,57457-04-2,57457-05-3,101775-72-8) + propionic acid anhydride (123-62-6) → (+/-)-[3r-ethyl-1-methyl-4t-phenyl-4c-propionyloxy-piperidine (468-50-8,468-51-9,51372-89-5)

Guidance literature:

DOI:10.1021/jo01362a053

upstream raw materials:

propionic acid anhydride

(+/-)-3c-ethyl-1-methyl-4-phenyl-piperidin-4r-ol

phenyllithium