Methyl 5-(2-methoxyphenyl)nicotinate

Base Information

Chemical Name:Methyl 5-(2-methoxyphenyl)nicotinate
CAS No.:93349-96-3
Molecular Formula:C14H13NO3
Molecular Weight:243.262
Hs Code.:2933399090
DSSTox Substance ID:DTXSID60602423
Wikidata:Q82499483
Mol file:93349-96-3.mol

Synonyms:Methyl 5-(2-methoxyphenyl)nicotinate;93349-96-3;methyl 5-(2-methoxyphenyl)pyridine-3-carboxylate;METHYL5-(2-METHOXYPHENYL)NICOTINATE;DTXSID60602423;AKOS004116410;DB-265461;J-522396;3-Pyridinecarboxylic acid, 5-(2-methoxyphenyl)-, methyl ester

Suppliers and Price of Methyl 5-(2-methoxyphenyl)nicotinate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
Methyl5-(2-methoxyphenyl)nicotinate 95+%
1g
$ 353.00

Chemenu
methyl5-(2-methoxyphenyl)nicotinate 95%
1g
$ 333.00

American Custom Chemicals Corporation
METHYL-5-(2-METHOXYPHENYL)NICOTINATE 95.00%
5MG
$ 500.24

Alichem
Methyl5-(2-methoxyphenyl)nicotinate
1g
$ 400.00

Total 7 raw suppliers

Chemical Property of Methyl 5-(2-methoxyphenyl)nicotinate

Chemical Property:

Boiling Point:357.8±32.0 °C(Predicted)
PKA:2.77±0.22(Predicted)
PSA：48.42000
Density:1.159±0.06 g/cm3(Predicted)
LogP:2.54380
Storage Temp.:2-8°C
XLogP3:2.3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:243.08954328
Heavy Atom Count:18
Complexity:282

Purity/Quality:

95+% ^*data from raw suppliers

Methyl5-(2-methoxyphenyl)nicotinate 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC=CC=C1C2=CC(=CN=C2)C(=O)OC

Technology Process of Methyl 5-(2-methoxyphenyl)nicotinate

There total 4 articles about Methyl 5-(2-methoxyphenyl)nicotinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 29681-44-5
5-bromo-3-pyridine carboxylic acid methyl ester

: 5720-06-9
2-Methoxyphenylboronic acid

: 93349-96-3
Methyl 5-(2-Methoxyphenyl)nicotinate

Guidance literature:: With triethylamine; palladium diacetate; 2*NEt3; In N,N-dimethyl-formamide; at 100 ℃; for 3h;
DOI:10.1021/jo00200a045

Reference yield:

: 59-67-6
nicotinic acid

: 93349-96-3
Methyl 5-(2-Methoxyphenyl)nicotinate

Guidance literature:: Multi-step reaction with 4 steps

1: SOCl₂ / neat (no solvent) / 24 h / Heating

2: bromine / 1 h / 150 °C

3: CH₂Cl₂ / 1. ice bath 2. 30 min reflux

4: 70 percent / NEt₃ / Pd(OAc)2, 2*NEt₃ / dimethylformamide / 3 h / 100 °C

With thionyl chloride; bromine; triethylamine; palladium diacetate; 2*NEt3; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo00200a045

Reference yield:

: 10400-19-8
3-pyridinecarbonyl chloride

: 93349-96-3
Methyl 5-(2-Methoxyphenyl)nicotinate

Guidance literature:: Multi-step reaction with 3 steps

1: bromine / 1 h / 150 °C

2: CH₂Cl₂ / 1. ice bath 2. 30 min reflux

3: 70 percent / NEt₃ / Pd(OAc)2, 2*NEt₃ / dimethylformamide / 3 h / 100 °C

With bromine; triethylamine; palladium diacetate; 2*NEt3; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo00200a045