(5RS)-5-(4-Methoxyphenyl)-3-Methyl-1-oxa-3-azaspiro-[5.5]undecane Hydrochloride

Base Information

Chemical Name:(5RS)-5-(4-Methoxyphenyl)-3-Methyl-1-oxa-3-azaspiro-[5.5]undecane Hydrochloride
CAS No.:93413-56-0
Molecular Formula:C17H25NO2.ClH
Molecular Weight:311.852
Hs Code.:
Mol file:93413-56-0.mol

Synonyms:Movento;Ultor;spirotetramat;spiro-venlafaxine hydrochloride;

Suppliers and Price of (5RS)-5-(4-Methoxyphenyl)-3-Methyl-1-oxa-3-azaspiro-[5.5]undecane Hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
5-(4-Methoxyphenyl)-3-methyl-1-oxa-3-azaspiro[5.5]undecaneHydrochloride
5mg
$ 700.00

TRC
5-(4-Methoxyphenyl)-3-methyl-1-oxa-3-azaspiro[5.5]undecaneHydrochloride
2.5mg
$ 375.00

American Custom Chemicals Corporation
(5RS)-5-(4-METHOXYPHENYL)-3-METHYL-1-OXA-3- AZASPIRO-[5.5]UNDECANE HYDROCHLORIDE 95.00%
10G
$ 1992.38

Total 11 raw suppliers

Chemical Property of (5RS)-5-(4-Methoxyphenyl)-3-Methyl-1-oxa-3-azaspiro-[5.5]undecane Hydrochloride

Chemical Property:

Melting Point:216 - 221°C
PSA：21.70000
LogP:4.14110
Storage Temp.:Hygroscopic, -20°C Freezer, Under inert atmosphere
Solubility.:Acetonitrile (Slightly), Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

99%, ^*data from raw suppliers

5-(4-Methoxyphenyl)-3-methyl-1-oxa-3-azaspiro[5.5]undecaneHydrochloride ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses 5-(4-Methoxyphenyl)-3-methyl-1-oxa-3-azaspiro[5.5]undecane Hydrochloride (Venlafaxine EP Impurity E) is a useful building block in the synthesis of various pharmaceuticals.

Technology Process of (5RS)-5-(4-Methoxyphenyl)-3-Methyl-1-oxa-3-azaspiro-[5.5]undecane Hydrochloride

There total 4 articles about (5RS)-5-(4-Methoxyphenyl)-3-Methyl-1-oxa-3-azaspiro-[5.5]undecane Hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 1-[aminomethyl-1-(methoxyphenyl)methyl]cyclohexanol

: 93413-56-0
(5RS)-5-(4-methoxyphenyl)-3-methyl-1-oxa-3-azaspiro[5,5]undecane hydrochloride

Guidance literature:: formaldehyd; 1-[aminomethyl-1-(methoxyphenyl)methyl]cyclohexanol; With formic acid; at 53 - 57 ℃;

With sodium hydroxide; In water; toluene;

With hydrogenchloride; In isopropyl alcohol;

Reference yield:

: 108-94-1,11119-77-0,9003-41-2,9075-99-4
cyclohexanone

: 93413-56-0
(5RS)-5-(4-methoxyphenyl)-3-methyl-1-oxa-3-azaspiro[5,5]undecane hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium methylate / methanol / 3 h / -5 - 0 °C

1.2: 49 h / -5 °C

2.1: hydrogen; acetic acid / palladium on carbon / 4 h / 43 - 47 °C / 8606.2 Torr

3.1: formic acid / 53 - 57 °C

With formic acid; hydrogen; sodium methylate; acetic acid; palladium on carbon; In methanol;

Reference yield:

: 104-47-2
p-methoxybenzylnitrile

: 93413-56-0
(5RS)-5-(4-methoxyphenyl)-3-methyl-1-oxa-3-azaspiro[5,5]undecane hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium methylate / methanol / 3 h / -5 - 0 °C

1.2: 49 h / -5 °C

2.1: hydrogen; acetic acid / palladium on carbon / 4 h / 43 - 47 °C / 8606.2 Torr

3.1: formic acid / 53 - 57 °C

With formic acid; hydrogen; sodium methylate; acetic acid; palladium on carbon; In methanol;