1H-Benzimidazole-2-carboxylic acid, 5-nitro-, methyl ester

Base Information

• Chemical Name: 1H-Benzimidazole-2-carboxylic acid, 5-nitro-, methyl ester
• CAS No.: 93521-65-4
• Molecular Formula: C9H7N3O4
• Molecular Weight: 221.17000
• Hs Code.: 2933990090
• Mol file: 93521-65-4.mol

Synonyms:Methyl 5-Nitro-1H-benzimidazole-2-carboxylate;Methyl5-Nitro-1H-benzimidazole-2-carboxylate;Methyl 5-nitro-1H-benzo[d]imidazole-2-carboxylate;

Chemical Property of 1H-Benzimidazole-2-carboxylic acid, 5-nitro-, methyl ester

Chemical Property:

• PSA: 100.80000
• LogP: 1.78090
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99%, ^*data from raw suppliers

Methyl5-Nitro-1H-benzo[d]imidazole-2-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Benzimidazole-2-carboxylic acid, 5-nitro-, methyl ester

There total 2 articles about 1H-Benzimidazole-2-carboxylic acid, 5-nitro-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

methanol (67-56-1) + 5-nitro-2-(trichloromethyl)-1H-benzo[d]imidazole (3584-84-7) → methyl 5-nitro-1H-benzo[d]imidazole-2-carboxylate (93521-65-4)

Guidance literature:

methanol; 5-nitro-2-(trichloromethyl)-1H-benzo[d]imidazole; With sodium carbonate; for 4h; Reflux;

With sodium hydrogencarbonate; for 4h; Reflux;

Reference yield:

4-Nitrophenylene-1,2-diamine (99-56-9) → methyl 5-nitro-1H-benzo[d]imidazole-2-carboxylate (93521-65-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: acetic acid / 20 °C

2.1: sodium carbonate / 4 h / Reflux

2.2: 4 h / Reflux

With sodium carbonate; acetic acid;

Reference yield: 78.0%

methyl 5-nitro-1H-benzo[d]imidazole-2-carboxylate (93521-65-4) → methyl 5-amino-1H-benzo[d]imidazole-2-carboxylate (292070-01-0)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃;

upstream raw materials:

methanol

5-nitro-2-(trichloromethyl)-1H-benzo[d]imidazole

4-Nitrophenylene-1,2-diamine

Downstream raw materials:

methyl 5-amino-1H-benzo[d]imidazole-2-carboxylate

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