4(3H)-Pyrimidinone, 5-methyl-2-(methylthio)-

Base Information

• Chemical Name: 4(3H)-Pyrimidinone, 5-methyl-2-(methylthio)-
• CAS No.: 20651-30-3
• Molecular Formula: C6H8N2OS
• Molecular Weight: 156.208
• Hs Code.: 2933599090
• Mol file: 20651-30-3.mol

Synonyms:4(1H)-Pyrimidinone,5-methyl-2-(methylthio)- (8CI,9CI);4-Pyrimidinol, 5-methyl-2-(methylthio)-(7CI);2-(Methylthio)-5-methyl-1,3-pyrimidin-6-one;5-Methyl-2-methylsulfanyl-3H-pyrimidin-4-one;NSC 46972;

Chemical Property of 4(3H)-Pyrimidinone, 5-methyl-2-(methylthio)-

Chemical Property:

• Refractive Index: 1.618
• PSA: 71.05000
• Density: 1.3 g/cm³
• LogP: 0.80020
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

97% ^*data from raw suppliers

5-Methyl-2-(methylthio)pyrimidin-4(3H)-one 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4(3H)-Pyrimidinone, 5-methyl-2-(methylthio)-

There total 14 articles about 4(3H)-Pyrimidinone, 5-methyl-2-(methylthio)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

5-methyl-2-thiouracil (636-26-0) + methyl iodide (74-88-4) → 2-methylthio-3,4-dihydro-5-methylpyrimidin-4-one (20651-30-3)

Guidance literature:

With potassium hydroxide; In ethanol; for 2h; Heating;

DOI:10.1080/10426500307818

Reference yield: 81.0%

5-methyl-2-thiouracil (636-26-0) + methyl iodide (74-88-4) → 2-(methylthio)-5-methylpyrimidin-4(1H)-one (20651-30-3)

Guidance literature:

With sodium hydroxide; In water; at 10 - 15 ℃; for 16.3333h;

DOI:10.1016/j.bmc.2011.10.002

Reference yield: 44.0%

4-(5-Methyl-2-methylsulfanyl-6-oxo-6H-pyrimidin-1-ylmethyl)-5-pyrrolidin-1-yl-4,5-dihydro-isoxazole-3-carboxylic acid ethyl ester (190070-16-7) → 2-methylthio-3,4-dihydro-5-methylpyrimidin-4-one (20651-30-3) + 5-Amino-4-(5-methyl-2-methylsulfanyl-6-oxo-6H-pyrimidin-1-ylmethyl)-4,5-dihydro-isoxazole-3-carboxylic acid amide + 4-(5-Methyl-2-methylsulfanyl-6-oxo-6H-pyrimidin-1-ylmethyl)-5-pyrrolidin-1-yl-4,5-dihydro-isoxazole-3-carboxylic acid amide

Guidance literature:

With ammonia; In methanol; at 0 ℃;

upstream raw materials:

5-methyl-2-thiouracil

methyl iodide

ethyl 2-chloro-2-(hydroxyimino)acetate

5-Methyl-2-methylsulfanyl-3-((E)-3-pyrrolidin-1-yl-allyl)-3H-pyrimidin-4-one

Downstream raw materials:

3,4-dihydro-2-hydrazino-5-methylpyrimidin-4-one

2,4-dihydroxy-5-methylpyrimidine

4-chloro-5-methyl-2-(methylsulfanyl)pyrimidine

4-[[(5-methyl-4(3H)-oxopyrimidin-2-yl)amino]methyl]benzonitrile

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