Liquiritigenin

Base Information Edit

Chemical Name:Liquiritigenin
CAS No.:578-86-9
Molecular Formula:C15H12O4
Molecular Weight:256.258
Hs Code.:29329990
UNII:T194LKP9W6
DSSTox Substance ID:DTXSID90206493
Nikkaji Number:J22.604A
Wikipedia:Liquiritigenin
Wikidata:Q6557526
Pharos Ligand ID:TJSKT4CUQ536
Metabolomics Workbench ID:27226
ChEMBL ID:CHEMBL252642
Mol file:578-86-9.mol

Synonyms:7,4'-dihydroxyflavanone;liquiritigenin

Suppliers and Price of Liquiritigenin

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Liquiritigenin
20mg
$ 390.00

Usbiological
Liquiritigenin
10mg
$ 489.00

TRC
Liquiritigenin
5mg
$ 165.00

Sigma-Aldrich
Liquiritigenin ≥97.0% (HPLC)
10mg
$ 226.00

Sigma-Aldrich
Liquiritigenin ≥97.0% (HPLC)
50mg
$ 602.00

Medical Isotopes, Inc.
Liquiritigenin 98%
1000 mg
$ 1317.00

Medical Isotopes, Inc.
Liquiritigenin 98%
20 mg
$ 517.00

JR MediChem
Liquiritigenin(NewProduct) 98%
100mg
$ 268.00

DC Chemicals
Liquiritigenin >98%,StandardReferencesGrade
20 mg
$ 280.00

CSNpharm
Liquiritigenin
5mg
$ 54.00

Total 95 raw suppliers

Chemical Property of Liquiritigenin Edit

Chemical Property:

Vapor Pressure:7.94E-12mmHg at 25°C
Melting Point:206-208 °C
Refractive Index:1.661
Boiling Point:529.5 °C at 760 mmHg
PKA:7.71±0.40(Predicted)
Flash Point:206.9 °C
PSA：66.76000
Density:1.386 g/cm³
LogP:2.80430
Storage Temp.:under inert gas (nitrogen or Argon) at 2-8°C
XLogP3:2.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:256.07355886
Heavy Atom Count:19
Complexity:335

Purity/Quality:

99% ^*data from raw suppliers

Liquiritigenin ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1C(OC2=C(C1=O)C=CC(=C2)O)C3=CC=C(C=C3)O
Isomeric SMILES:C1[C@H](OC2=C(C1=O)C=CC(=C2)O)C3=CC=C(C=C3)O
Recent ClinicalTrials:A Study of MF101 in Postmenopausal Women
Description Liquiritigenin is an active estrogenic component in extracts of Glycyrrhizae radix. Glycyrrhizae radix (G. radix, licorice, liquorice) is frequently used for life-enhancing properties, for the treatment of injury or swelling, for detoxification in traditional Oriental medicine, as well as a food supplement in many of the countries in the world.? Liquiritigenin is a selective estrogen receptor-β (ERβ) agonist.? Liquiritigenin activates multiple ER regulatory elements and native target genes with ERβ but not ERα. The ERβ-selectivity of liquiritigenin is due to the selective recruitment of the coactivator steroid receptor coactivator-2 to target genes. As the targeting ERβ is associated with anti-inflammatory effects, liquiritigenin exerts anti-inflammatory effects. Liquiritigenin is also reported to antihyperlipidemic, antiallergic and antihepatocellular carcinoma effects.
Uses Liquiritigenin has been used:to study its inhibitory effect on tumor metastasis in the treatment of colorectal canceras a reference standard for ultra-performance liquid chromatography (UPLC) of Chaihu-Shugan-San (CSS) extractas a potential antiviral drug against hepatitis C virus (HCV) infection

Technology Process of Liquiritigenin

There total 12 articles about Liquiritigenin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%