Chemical Property of Liquiritigenin
Chemical Property:
- Vapor Pressure:7.94E-12mmHg at 25°C
- Melting Point:206-208 °C
- Refractive Index:1.661
- Boiling Point:529.5 °C at 760 mmHg
- PKA:7.71±0.40(Predicted)
- Flash Point:206.9 °C
- PSA：66.76000
- Density:1.386 g/cm3
- LogP:2.80430
- Storage Temp.:under inert gas (nitrogen or Argon) at 2-8°C
- XLogP3:2.2
- Hydrogen Bond Donor Count:2
- Hydrogen Bond Acceptor Count:4
- Rotatable Bond Count:1
- Exact Mass:256.07355886
- Heavy Atom Count:19
- Complexity:335
- Purity/Quality:
-
≥98% *data from raw suppliers
Liquiritigenin *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:C1C(OC2=C(C1=O)C=CC(=C2)O)C3=CC=C(C=C3)O
- Isomeric SMILES:C1[C@H](OC2=C(C1=O)C=CC(=C2)O)C3=CC=C(C=C3)O
- Recent ClinicalTrials:A Study of MF101 in Postmenopausal Women
-
Description
Liquiritigenin is an active estrogenic component in extracts of Glycyrrhizae radix. Glycyrrhizae radix (G. radix, licorice, liquorice) is frequently used for life-enhancing properties, for the treatment of injury or swelling, for detoxification in traditional Oriental medicine, as well as a food supplement in many of the countries in the world.? Liquiritigenin is a selective estrogen receptor-β (ERβ) agonist.? Liquiritigenin activates multiple ER regulatory elements and native target genes with ERβ but not ERα. The ERβ-selectivity of liquiritigenin is due to the selective recruitment of the coactivator steroid receptor coactivator-2 to target genes.
As the targeting ERβ is associated with anti-inflammatory effects, liquiritigenin exerts anti-inflammatory effects. Liquiritigenin is also reported to antihyperlipidemic, antiallergic and antihepatocellular carcinoma effects.
-
Uses
Liquiritigenin has been used:to study its inhibitory effect on tumor metastasis in the treatment of colorectal canceras a reference standard for ultra-performance liquid chromatography (UPLC) of Chaihu-Shugan-San (CSS) extractas a potential antiviral drug against hepatitis C virus (HCV) infection
