54149-18-7Relevant articles and documents
Catalytic Asymmetric Csp3?H Functionalization under Photoredox Conditions by Radical Translocation and Stereocontrolled Alkene Addition
Wang, Chuanyong,Harms, Klaus,Meggers, Eric
, p. 13495 - 13498 (2016)
This work demonstrates how photoredox-mediated C(sp3)?H activation through radical translocation can be combined with asymmetric catalysis. Upon irradiation with visible light, α,β-unsaturated N-acylpyrazoles react with N-alkoxyphthalimides in the presence of a rhodium-based chiral Lewis acid catalyst and the photosensitizer fac-[Ir(ppy)3] to provide a C?C bond-formation product with high enantioselectivity (up to 97 % ee) and, where applicable, with some diastereoselectivity (3.0:1 d.r.). Mechanistically, the synthetic strategy exploits a radical translocation (1,5-hydrogen transfer) from an oxygen-centered to a carbon-centered radical with a subsequent stereocontrolled radical alkene addition.
HMOX1 inducers
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Page/Page column 161, (2020/09/18)
The present invention is related to compounds of structure (I) as heme oxygenase 1 (HMOX 1) inducers. The present invention is also related a method of controlling the activity or the amount, or both the activity and the amount, of heme-oxygenase 1 in a mammalian subject. The definitions of the variables are provided herein.
CONTROLLED RELEASE OF ACTIVE COMPOUNDS FROM DYNAMIC MIXTURES
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, (2010/09/17)
The present invention relates to a dynamic mixture in the form of a dynamic mixture obtained by reacting together, in the presence of water, at least one O-substituted hydroxylamine or S-substituted thiohydroxylamine derivative with at least one perfuming