6-((2-Chlorophenoxy)(phenyl)Methyl)Morpholin-3-one

Base Information

• Chemical Name: 6-((2-Chlorophenoxy)(phenyl)Methyl)Morpholin-3-one
• CAS No.: 93886-33-0
• Molecular Formula: C₁₇H₁₆ClNO₃
• Molecular Weight: 317.772
• Hs Code.: 2934999090
• Mol file: 93886-33-0.mol

Synonyms:6-((2-Chlorophenoxy)(phenyl)methyl)morpholin-3-one;

Chemical Property of 6-((2-Chlorophenoxy)(phenyl)Methyl)Morpholin-3-one

Chemical Property:

• Boiling Point: 527.5±45.0 °C (760 mmHg)
• PSA: 47.56000
• Density: 1.274±0.06 g/cm3 (20 °C, 760 mmHg)
• LogP: 3.30390

Purity/Quality:

99% ^*data from raw suppliers

6-((2-Chlorophenoxy)(phenyl)methyl)morpholin-3-one 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-((2-Chlorophenoxy)(phenyl)Methyl)Morpholin-3-one

There total 9 articles about 6-((2-Chlorophenoxy)(phenyl)Methyl)Morpholin-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-Chloro-N-[3-(2-chloro-phenoxy)-2-hydroxy-3-phenyl-propyl]-acetamide (93852-41-6) → 6-[(2-Chloro-phenoxy)-phenyl-methyl]-morpholin-3-one (93886-33-0)

Guidance literature:

With potassium tert-butylate; In tert-butyl alcohol; for 1h; Yield given; Ambient temperature;

Reference yield:

2-monochlorophenol (95-57-8) → 6-[(2-Chloro-phenoxy)-phenyl-methyl]-morpholin-3-one (93886-33-0)

Guidance literature:

Multi-step reaction with 8 steps

1: 1.) NaH / 1.) dimethylacetamide, 1-1.5 h, 40 deg C; 2.) dimethylacetamide, 5 h, 90 deg C

2: KOH / methanol / 20 h / Ambient temperature

3: SOCl₂ / 16 h / Ambient temperature

4: LiAlH(O-tBu)3 / bis-(2-methoxy-ethyl) ether / 0.5 h / -60 °C

5: 1.) Na₂S₂O₅; 2.) KCN / 1.) H₂O, EtOH, 16 h, 55 deg C; 2.) H₂O, EtOH, 7 h, reflux

6: LiAlH₄ / diethyl ether; tetrahydrofuran / also with BH₃; 1.) 16 h, RT; 2.) 1 h, 40 deg C

7: Et₃N / CH₂Cl₂ / 0.5 h / -5 °C

8: t-BuOK / 2-methyl-propan-2-ol / 1 h / Ambient temperature

With potassium cyanide; sodium metabisulfite; potassium hydroxide; lithium aluminium tetrahydride; thionyl chloride; potassium tert-butylate; sodium hydride; lithium tri-t-butoxyaluminum hydride; triethylamine; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; diethylene glycol dimethyl ether; tert-butyl alcohol;

Reference yield:

α-(2-Chlorphenoxy)phenylessigsaeure (17639-01-9) → 6-[(2-Chloro-phenoxy)-phenyl-methyl]-morpholin-3-one (93886-33-0)

Guidance literature:

Multi-step reaction with 6 steps

1: SOCl₂ / 16 h / Ambient temperature

2: LiAlH(O-tBu)3 / bis-(2-methoxy-ethyl) ether / 0.5 h / -60 °C

3: 1.) Na₂S₂O₅; 2.) KCN / 1.) H₂O, EtOH, 16 h, 55 deg C; 2.) H₂O, EtOH, 7 h, reflux

4: LiAlH₄ / diethyl ether; tetrahydrofuran / also with BH₃; 1.) 16 h, RT; 2.) 1 h, 40 deg C

5: Et₃N / CH₂Cl₂ / 0.5 h / -5 °C

6: t-BuOK / 2-methyl-propan-2-ol / 1 h / Ambient temperature

With potassium cyanide; sodium metabisulfite; lithium aluminium tetrahydride; thionyl chloride; potassium tert-butylate; lithium tri-t-butoxyaluminum hydride; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane; diethylene glycol dimethyl ether; tert-butyl alcohol;

upstream raw materials:

2-Chloro-N-[3-(2-chloro-phenoxy)-2-hydroxy-3-phenyl-propyl]-acetamide

2-monochlorophenol

α-(2-Chlorphenoxy)phenylessigsaeure

ethyl 2-chloro-2-phenylacetate

Downstream raw materials:

2-[(2-Chloro-phenoxy)-phenyl-methyl]-morpholine; hydrochloride

Refernces