2,4-dimethoxy-6-methyl-3-(propan-2-yl)phenol

Base Information

• Chemical Name: 2,4-dimethoxy-6-methyl-3-(propan-2-yl)phenol
• CAS No.: 135626-41-4
• Molecular Formula: C12H18O3
• Molecular Weight: 210.2695
• Mol file: 135626-41-4.mol

Synonyms:

Chemical Property of 2,4-dimethoxy-6-methyl-3-(propan-2-yl)phenol

Chemical Property:

• Vapor Pressure: 4.62E-05mmHg at 25°C
• Boiling Point: 339.6°Cat760mmHg
• Flash Point: 159.2°C
• Density: 1.039g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,4-dimethoxy-6-methyl-3-(propan-2-yl)phenol

There total 13 articles about 2,4-dimethoxy-6-methyl-3-(propan-2-yl)phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

6-(hydroxymethyl)-3-isopropyl-2,4-dimethoxyphenol (914618-38-5) → 2-isopropyl-4-hydroxy-5-methyl resorcinol dimethyl ether (135626-41-4)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 18h; Inert atmosphere;

DOI:10.1021/ol202641y

Reference yield: 91.0%

6-[(dibenzylamino)methyl]-3-isopropyl-2,4-dimethoxyphenol (1377042-17-5) → 2-isopropyl-4-hydroxy-5-methyl resorcinol dimethyl ether (135626-41-4)

Guidance literature:

With sodium cyanoborohydride; In 2-methyl-propan-1-ol; for 4h; Reflux; Inert atmosphere;

DOI:10.1055/s-0031-1290611

Reference yield: 72.0%

2,4-dibromo-3-isopropyl-6-methyl phenol (70454-10-3) + sodium methylate (124-41-4) → 2-isopropyl-4-hydroxy-5-methyl resorcinol dimethyl ether (135626-41-4)

Guidance literature:

With copper(l) iodide; In methanol; N,N-dimethyl-formamide; at 110 ℃; for 48h;

DOI:10.1080/00304949609356526

upstream raw materials:

1-(3-isopropyl-2,4-dimethoxy-6-methyl-phenyl)-ethanol

2,4-dibromo-3-isopropyl-6-methyl phenol

sodium methylate

2-isopropyl-4-methoxycarbonyl-5-methyl-6-hydroxy resorcinol dimethyl ether

Downstream raw materials:

C₂₄H₃₂O₆

Refernces

• 1、 Osipov, Dmitry V.,Osyanin, Vitaly A.,Klimochkin, Yuri N.. "Easy access to (±)-schefflone and espintanol". . p. 917 - 919. Retrieved 2012/06/04.
• 2、 Soederberg, Bjoern C.,Fields, Shari L.. "Expedient syntheses of espintanol, p-methoxycarvacrol and thymoquinol dimethyl ether". . p. 221 - 225. Retrieved 2007/10/03.