1-Bromo-2-(2-methylprop-1-en-1-yl)cyclohex-1-ene

Base Information

• Chemical Name: 1-Bromo-2-(2-methylprop-1-en-1-yl)cyclohex-1-ene
• CAS No.: 94223-23-1
• Molecular Formula: C10H15Br
• Molecular Weight: 215.133
• DSSTox Substance ID: DTXSID30538003
• Mol file: 94223-23-1.mol

Synonyms:94223-23-1;1-Bromo-2-(2-methylprop-1-en-1-yl)cyclohex-1-ene;DTXSID30538003

Chemical Property of 1-Bromo-2-(2-methylprop-1-en-1-yl)cyclohex-1-ene

Chemical Property:

• Boiling Point: 80 °C(Press: 1 Torr)
• PSA: 0.00000
• Density: 1.325±0.06 g/cm3(Predicted)
• LogP: 4.17560
• XLogP3: 3.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 0
• Rotatable Bond Count: 1
• Exact Mass: 214.03571
• Heavy Atom Count: 11
• Complexity: 195

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=CC1=C(CCCC1)Br)C

Technology Process of 1-Bromo-2-(2-methylprop-1-en-1-yl)cyclohex-1-ene

There total 3 articles about 1-Bromo-2-(2-methylprop-1-en-1-yl)cyclohex-1-ene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

2-bromocyclohex-1-ene-1-carbaldehyde (38127-47-8) + isopropyltriphenylphosphonium iodide (24470-78-8) → 1-bromo-2-(2-methyl-propenyl)-cyclohexene (94223-23-1)

Guidance literature:

isopropyltriphenylphosphonium iodide; With n-butyllithium; In tetrahydrofuran; hexane; at 0 - 23 ℃;

2-bromocyclohex-1-ene-1-carbaldehyde; In tetrahydrofuran; hexane; at 0 - 23 ℃;

DOI:10.1021/ol061248h

Reference yield: 79.0%

2-bromocyclohex-1-ene-1-carbaldehyde (38127-47-8) + isopropyltriphenylphosphonium bromide (1530-33-2) → 1-bromo-2-(2-methyl-propenyl)-cyclohexene (94223-23-1)

Guidance literature:

With n-butyllithium; In diethyl ether; 1.) 0 deg C 2.) R_.T_., 1 h 3.) 0 deg C, 1 h 4.) R_.T_., 2 h 5.) reflux, 1 h;

DOI:10.1016/S0040-4020(01)82434-0

Reference yield:

cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) → 1-bromo-2-(2-methyl-propenyl)-cyclohexene (94223-23-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: PBr₃ / CHCl₃ / 1 h / 0 °C

1.2: 81 percent / CHCl₃ / 8 h / 20 °C

2.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / 0 °C

2.2: 80 percent / tetrahydrofuran; hexane / 2 h / 0 °C

With n-butyllithium; phosphorus tribromide; In tetrahydrofuran; hexane; chloroform;

DOI:10.1021/ja062515h

upstream raw materials:

2-bromocyclohex-1-ene-1-carbaldehyde

isopropyltriphenylphosphonium bromide

isopropyltriphenylphosphonium iodide

cyclohexanone

Downstream raw materials:

2-(2-methylprop-1-enyl)cyclohex-1-ene-1-carbaldehyde

1-[2-(2-methyl-propenyl)-cyclohex-1-enyl]-prop-2-yn-1-ol

1-[2-(2-methyl-propenyl)-cyclohex-1-enyl]-3-trimethylsilanyl-prop-2-yn-1-ol

1-formyl-2-(2-methylpropenyl)cylohexene tosylhydrazone