6,N2,N2,N4,N4-pentamethyl-5-nitro-pyrimidine-2,4-diyldiamine

Base Information

• Chemical Name: 6,N2,N2,N4,N4-pentamethyl-5-nitro-pyrimidine-2,4-diyldiamine
• CAS No.: 94320-77-1
• Molecular Formula: C₉H₁₅N₅O₂
• Molecular Weight: 225.25
• Mol file: 94320-77-1.mol

Synonyms:6,N2,N2,N4,N4-Pentamethyl-5-nitro-pyrimidin-2,4-diyldiamin;6,N2,N2,N4,N4-Pentamethyl-5-nitro-pyrimidine-2,4-diamine;

Chemical Property of 6,N2,N2,N4,N4-pentamethyl-5-nitro-pyrimidine-2,4-diyldiamine

Chemical Property:

• Melting Point: 122 - 123 °C (petroleum ether)
• PSA: 78.08000
• LogP: 1.34840

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6,N2,N2,N4,N4-pentamethyl-5-nitro-pyrimidine-2,4-diyldiamine

There total 1 articles about 6,N2,N2,N4,N4-pentamethyl-5-nitro-pyrimidine-2,4-diyldiamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,4-dichloro-6-methyl-5-nitropyrimidine (13162-26-0) + dimethyl amine (124-40-3) → 6,N2,N2,N4,N4-pentamethyl-5-nitro-pyrimidine-2,4-diyldiamine (94320-77-1)

Guidance literature:

DOI:10.1039/jr9540004116

Reference yield:

6,N2,N2,N4,N4-pentamethyl-5-nitro-pyrimidine-2,4-diyldiamine (94320-77-1) → 2-(6,8-Bis-dimethylamino-pyrimido[5,4-d][1,2,3]triazin-4-ylsulfanyl)-1-phenyl-ethanone (94321-07-0)

Guidance literature:

Multi-step reaction with 5 steps

1: hydrogen / Raney nickel / methanol

2: 1.) hydrochloric acid, isopentyl nitrite, 2.) ammonium hydroxide / 1.) ice cooling, ethanol, 16 h, 2.) 2 h

3: 78 percent / thionyl chloride / 16 h

4: 85 percent / sodium hydrogen sulphide / methanol / 16 h

5: 1.) potassium carbonate, water / 2.) 30 min, ethanol

With hydrogenchloride; ammonium hydroxide; sodium hydrogensulfide; thionyl chloride; water; hydrogen; potassium carbonate; isopentyl nitrite; nickel; In methanol;

Reference yield:

6,N2,N2,N4,N4-pentamethyl-5-nitro-pyrimidine-2,4-diyldiamine (94320-77-1) → N4-Benzyl-N6,N6,N8,N8-tetramethyl-pyrimido[5,4-d][1,2,3]triazine-4,6,8-triamine (94320-91-9)

Guidance literature:

Multi-step reaction with 4 steps

1: hydrogen / Raney nickel / methanol

2: 1.) hydrochloric acid, isopentyl nitrite, 2.) ammonium hydroxide / 1.) ice cooling, ethanol, 16 h, 2.) 2 h

3: 78 percent / thionyl chloride / 16 h

4: 56 percent / ethanol / 1 h / Heating

With hydrogenchloride; ammonium hydroxide; thionyl chloride; hydrogen; isopentyl nitrite; nickel; In methanol; ethanol;

upstream raw materials:

2,4-dichloro-6-methyl-5-nitropyrimidine

dimethyl amine

Downstream raw materials:

N⁴-Benzyl-N⁶,N⁶,N⁸,N⁸-tetramethyl-pyrimido[5,4-d][1,2,3]triazine-4,6,8-triamine

2-(6,8-Bis-dimethylamino-pyrimido[5,4-d][1,2,3]triazin-4-ylsulfanyl)-1-phenyl-ethanone