ethyl 5-(3-methyl-5-isoxazolyl)-1H-pyrrole-2-carboxylate

Base Information

Chemical Name:ethyl 5-(3-methyl-5-isoxazolyl)-1H-pyrrole-2-carboxylate
CAS No.:94405-09-1
Molecular Formula:C11H12N2O3
Molecular Weight:220.22500
Hs Code.:
Mol file:94405-09-1.mol

Synonyms:5-(3-Methyl-isoxazol-5-yl)-1H-pyrrole-2-carboxylic acid ethyl ester;

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Chemical Property of ethyl 5-(3-methyl-5-isoxazolyl)-1H-pyrrole-2-carboxylate

Chemical Property:

Melting Point:142 - 143 °C (CHCl3)
PSA：68.12000
LogP:2.15480

Purity/Quality:

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Technology Process of ethyl 5-(3-methyl-5-isoxazolyl)-1H-pyrrole-2-carboxylate

There total 5 articles about ethyl 5-(3-methyl-5-isoxazolyl)-1H-pyrrole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 141-52-6
sodium ethanolate

: 94405-08-0
2-(3-methylisoxazol-5-yl)-5-(trichloroacetyl)pyrrole

: 94405-09-1
ethyl 5-(3-methylisoxazol-5-yl)pyrrole-2-carboxylate

Guidance literature:: In ethanol; for 0.5h;
DOI:10.1021/jo00204a001

Reference yield:

: 22441-25-4
1-(1H-pyrrol-2-yl)butane-1,3-dione

: 94405-09-1
ethyl 5-(3-methylisoxazol-5-yl)pyrrole-2-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: hydroxylamine hydrochloride, Et₃N / methanol / 0.67 h / Heating

2: p-toluenesulfonic acid / methanol

3: 88 percent / 1,2-dichloro-ethane / 2 h / Heating

4: 99 percent / ethanol / 0.5 h

With hydroxylamine hydrochloride; toluene-4-sulfonic acid; triethylamine; In methanol; ethanol; 1,2-dichloro-ethane;
DOI:10.1021/jo00204a001

Reference yield:

: 94405-07-9
1-(1H-Pyrrol-2-yl)-butane-1,3-dione 3-oxime

: 94405-09-1
ethyl 5-(3-methylisoxazol-5-yl)pyrrole-2-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: p-toluenesulfonic acid / methanol

2: 88 percent / 1,2-dichloro-ethane / 2 h / Heating

3: 99 percent / ethanol / 0.5 h

With toluene-4-sulfonic acid; In methanol; ethanol; 1,2-dichloro-ethane;
DOI:10.1021/jo00204a001